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Best South America Cruises

Showing 376-400 of 424 results
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53-night south america cruise
$35,999
Seabourn – Seabourn Quest
4.6 (43)
Departs Feb 05, 2028 from Santiago (Valparaiso), Chile
Up to 1 deal
11-night south america cruise + tour
$17,998
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Feb 14, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
21-night south america cruise + tour
$29,998
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Feb 24, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
13-night south america cruise + tour
$18,398
Seabourn – Seabourn Venture
5.0 (2)
Departs Feb 28, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
25-night south america cruise
$16,999
Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 04, 2028 from Buenos Aires, Argentina
Up to 2 deals
55-night south america cruise
$36,999
Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 04, 2028 from Buenos Aires, Argentina
Up to 2 deals
63-night south america cruise
$42,299
Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 04, 2028 from Buenos Aires, Argentina
Up to 2 deals
11-night south america cruise + tour
$14,998
Seabourn – Seabourn Venture
5.0 (2)
Departs Mar 11, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
11-night south america cruise + tour
$14,998
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Mar 15, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
26-night south america cruise + tour
$26,998
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Mar 25, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$3,349
AmaWaterways – AmaMelodia
Departs Dec 30, 2026 from Cartagena, Spain
7-night south america cruise
$5,198
AmaWaterways – AmaMelodia
Departs Jan 06, 2027 from Barranquilla, Colombia
Up to 1 deal
20-night south america cruise
$25,400
Silversea – Silver Nova
5.0 (5)
Departs Jan 18, 2027 from Bridgetown, Barbados
Up to 2 deals including an Avoya Exclusive
10-night south america cruise
$12,100
Silversea – Silver Nova
5.0 (5)
Departs Feb 07, 2027 from Rio de Janeiro, Brazil
Up to 1 deal
16-night south america cruise
$15,000
Silversea – Silver Nova
5.0 (5)
Departs Feb 17, 2027 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$6,398
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Feb 27, 2027 from Cartagena, Spain
Up to 1 deal
4-night south america cruise
$549
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 14, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$5,448
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 20, 2027 from Barranquilla, Colombia
Up to 1 deal
1-night south america cruise
$99
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 01, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$4,698
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 10, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 05, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,799
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 08, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 15, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 19, 2027 from Cartagena, Spain
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 26, 2027 from Barranquilla, Colombia
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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