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Best South America Cruises

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2-night south america cruise
$389
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$789
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$989
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 03, 2027 from ITAJAI
Up to 2 deals
7-night south america cruise
$1,075
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 16, 2027 from Paranagua, Brazil
Up to 2 deals
3-night south america cruise
$639
MSC Cruises – MSC Divina
3.8 (92)
Departs Jan 29, 2027 from Santos, Brazil
Up to 1 deal
4-night south america cruise
$819
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 05, 2027 from Santos, Brazil
Up to 1 deal
3-night south america cruise
$589
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 09, 2027 from Santos, Brazil
Up to 2 deals
3-night south america cruise
$649
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 12, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$859
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 16, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
3-night south america cruise
$649
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 19, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$779
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 20, 2027 from Paranagua, Brazil
Up to 2 deals
7-night south america cruise
$779
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 21, 2027 from ITAJAI
Up to 3 deals
3-night south america cruise
$559
MSC Cruises – MSC Divina
3.8 (92)
Departs Feb 22, 2027 from Santos, Brazil
Up to 2 deals
7-night south america cruise
$1,269
MSC Cruises – MSC Seaview
4.6 (5)
Departs Feb 22, 2027 from CAMBORIU
Up to 2 deals
7-night south america cruise
$769
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 28, 2027 from ITAJAI
Up to 2 deals
3-night south america cruise
$589
MSC Cruises – MSC Divina
3.8 (92)
Departs Mar 01, 2027 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,249
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 07, 2027 from ITAJAI
Up to 1 deal
6-night south america cruise
$649
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 09, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
1-night south america cruise
$189
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 13, 2027 from Paranagua, Brazil
Up to 1 deal
2-night south america cruise
$249
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 13, 2027 from Paranagua, Brazil
Up to 1 deal
1-night south america cruise
$189
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 14, 2027 from ITAJAI
Up to 1 deal
4-night south america cruise
$639
MSC Cruises – MSC Musica
3.5 (4)
Departs Apr 01, 2027 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$5,498
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 22, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,799
AmaWaterways – AmaMelodia
Departs Sep 08, 2027 from Cartagena, Colombia
Up to 1 deal
7-night south america cruise
$1,711
MSC Cruises – MSC Musica
3.5 (4)
Departs Dec 29, 2026 from Rio de Janeiro, Brazil
Up to 1 deal

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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