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Best South America Cruises

Showing 451-475 of 533 results
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7-night south america cruise
$981
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 02, 2027 from Paranagua, Brazil
Up to 1 deal
7-night south america cruise
$981
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 05, 2027 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$981
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 09, 2027 from Paranagua, Brazil
Up to 1 deal
7-night south america cruise
$981
MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 12, 2027 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$771
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 23, 2027 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$761
MSC Cruises – MSC Musica
3.5 (4)
Departs Feb 27, 2027 from Paranagua, Brazil
Up to 1 deal
7-night south america cruise
$761
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 02, 2027 from Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$761
MSC Cruises – MSC Musica
3.5 (4)
Departs Mar 06, 2027 from Paranagua, Brazil
Up to 1 deal
28-night south america cruise
$19,598
Seabourn – Seabourn Quest
4.6 (43)
Departs Feb 05, 2028 from Santiago (Valparaiso), Chile
Up to 1 deal
11-night south america cruise
$11,280
Silversea – Silver Cloud
4.3 (16)
Departs Feb 29, 2028 from Puerto Williams, Chile
14-night south america cruise
$7,099
50% Off List
Oceania Cruises – Aurelia
Departs Nov 08, 2028 from Bridgetown, Barbados
Up to 1 deal
10-night south america cruise
$5,099
50% Off List
Oceania Cruises – Aurelia
Departs Nov 22, 2028 from Rio de Janeiro, Brazil
Up to 1 deal
20-night south america cruise
$9,949
50% Off List
Oceania Cruises – Aurelia
Departs Dec 02, 2028 from Buenos Aires, Argentina
Up to 1 deal
15-night south america cruise
$7,299
50% Off List
Oceania Cruises – Aurelia
Departs Dec 22, 2028 from Lima (Callao), Peru
Up to 1 deal
25-night south america cruise
$18,499
60% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 07, 2029 from Miami, Florida
Up to 2 deals
17-night south america cruise
$13,999
60% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 2 deals
25-night south america cruise
$19,599
62% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 2 deals
8-night south america cruise
$6,699
64% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Feb 18, 2029 from Santiago (Valparaiso), Chile
Up to 2 deals
33-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
Secret Rate
15-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
Secret Rate
15-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 22, 2026 from San Antonio, Chile
Up to 2 deals including an Avoya Exclusive
Secret Rate
17-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 06, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
Secret Rate
17-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 23, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
Secret Rate
20-night south america cruise + tour
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 02, 2026 from Rio de Janeiro, Brazil
Up to 1 deal including an Avoya Exclusive
21-night south america cruise
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Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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