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Best South America Cruises

Showing 76-100 of 440 results
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7-night south america cruise
$4,299
AmaWaterways – AmaMelodia
Departs Apr 07, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 14, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 21, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,799
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 24, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,348
AmaWaterways – AmaMagdalena
5.0 (1)
Departs May 01, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs May 12, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,549
AmaWaterways – AmaMelodia
Departs Jun 02, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,649
AmaWaterways – AmaMelodia
Departs Jun 09, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,448
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 26, 2027 from Barranquilla, Colombia
Up to 1 deal
22-night south america cruise
$11,520
69% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Nov 09, 2026 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
18-night south america cruise
$1,769
Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
33-night south america cruise
$3,641
Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$2,889
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 05, 2026 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
15-night south america cruise
$2,072
Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$2,283
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
15-night south america cruise
$3,225
62% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Dec 19, 2026 from Miami, Florida
Up to 5 deals including an Avoya Exclusive
Secret Rate
15-night south america cruise
$2,002
Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 22, 2026 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$5,072
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 02, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
21-night south america cruise
$5,567
57% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Jan 03, 2027 from Lima (Callao), Peru
Up to 6 deals including Avoya Exclusives
18-night south america cruise
$8,385
74% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 04, 2027 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
14-night south america cruise
$12,494
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 16, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
17-night south america cruise
$4,237
Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 23, 2027 from Buenos Aires, Argentina
Up to 7 deals including an Avoya Exclusive
Secret Rate
21-night south america cruise
$6,599
50% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Jan 24, 2027 from Buenos Aires, Argentina
Up to 5 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$17,271
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 30, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
22-night south america cruise
$4,799
Holland America – Oosterdam
4.2 (212)
Departs Feb 01, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
Avoya Exclusive Rate

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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