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Best Panama Canal Cruises

Showing 126-150 of 229 results
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14-night panama canal cruise
$1,804
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 5 deals including Avoya Exclusives
21-night panama canal cruise
$2,534
Holland America – Eurodam
4.3 (283)
Departs Apr 03, 2027 from Fort Lauderdale, Florida
Up to 5 deals including Avoya Exclusives
17-night panama canal cruise
$2,194
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Apr 11, 2027 from Fort Lauderdale, Florida
Up to 5 deals including Avoya Exclusives
21-night panama canal cruise
$3,039
Holland America – Eurodam
4.3 (283)
Departs Oct 02, 2027 from Seattle, Washington
20-night panama canal cruise
$2,919
Holland America – Eurodam
4.3 (283)
Departs Oct 03, 2027 from Vancouver, BC, Canada
16-night panama canal cruise
$2,534
Holland America – Eurodam
4.3 (283)
Departs Oct 07, 2027 from San Diego, California
11-night panama canal cruise
$2,188
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Nov 22, 2027 from Fort Lauderdale, Florida
Up to 4 deals
15-night panama canal cruise
$2,674
Holland America – Zaandam
4.5 (132)
Departs Dec 18, 2027 from San Diego, California
11-night panama canal cruise
$1,988
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Jan 03, 2028 from Fort Lauderdale, Florida
Up to 4 deals
14-night panama canal cruise
$2,634
Holland America – Zaandam
4.5 (132)
Departs Jan 16, 2028 from Fort Lauderdale, Florida
11-night panama canal cruise
$2,137
Celebrity Cruises – Celebrity Ascent
5.0 (22)
Departs Feb 14, 2028 from Fort Lauderdale, Florida
Up to 4 deals
16-night panama canal cruise
$2,864
Holland America – Eurodam
4.3 (283)
Departs Apr 01, 2028 from Fort Lauderdale, Florida
22-night panama canal cruise
$3,409
Holland America – Eurodam
4.3 (283)
Departs Apr 01, 2028 from Fort Lauderdale, Florida
7-night panama canal cruise
$5,217
Windstar Cruises – Star Pride
4.5 (95)
Departs Mar 02, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
6-night panama canal cruise
$2,338
Windstar Cruises – Star Pride
4.5 (95)
Departs Mar 09, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
11-night panama canal cruise
$1,299
Norwegian Cruise Line – Norwegian Jewel
4.4 (174)
Departs Mar 15, 2026 from Miami, Florida
Up to 7 deals including an Avoya Exclusive
8-night panama canal cruise
$4,724
Windstar Cruises – Star Seeker
Departs Apr 20, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$6,443
Windstar Cruises – Star Seeker
Departs Apr 20, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
25-night panama canal cruise
$15,104
Windstar Cruises – Star Seeker
Departs Apr 20, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
21-night panama canal cruise
$2,234
Holland America – Nieuw Amsterdam
4.3 (198)
Departs Sep 27, 2026 from Vancouver, BC, Canada
Up to 3 deals including Avoya Exclusives
20-night panama canal cruise
$2,109
Holland America – Eurodam
4.3 (283)
Departs Oct 04, 2026 from Vancouver, BC, Canada
Up to 4 deals including Avoya Exclusives
16-night panama canal cruise
$1,779
Holland America – Eurodam
4.3 (283)
Departs Oct 08, 2026 from San Diego, California
Up to 5 deals including Avoya Exclusives
8-night panama canal cruise
$3,565
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$4,069
Windstar Cruises – Wind Star
4.6 (89)
Departs Dec 12, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$5,727
Windstar Cruises – Star Legend
4.5 (86)
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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