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Best Panama Canal Cruises

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7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 17, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 24, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Jan 31, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 07, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$3,557
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 14, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
7-night panama canal cruise
$2,361
Windstar Cruises – Star Pride
4.5 (95)
Departs Feb 21, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
35-night panama canal cruise
$2,819
51% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 06, 2026 from Rome (Civitavecchia), Italy
Up to 3 deals
34-night panama canal cruise
$3,589
46% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 07, 2026 from Genoa, Italy
Up to 3 deals
33-night panama canal cruise
$3,209
43% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 08, 2026 from Marseille, France
Up to 3 deals
32-night panama canal cruise
$3,209
42% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 09, 2026 from Barcelona, Spain
Up to 3 deals
20-night panama canal cruise
$1,430
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 14, 2026 from Miami, Florida
Up to 3 deals including Avoya Exclusives
18-night panama canal cruise
$1,392
62% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 23, 2026 from Miami, Florida
Up to 2 deals
21-night panama canal cruise
$1,499
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 4 deals including Avoya Exclusives
19-night panama canal cruise
$1,832
49% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Sep 28, 2026 from Seattle, Washington, United States
Up to 3 deals
18-night panama canal cruise
$1,817
48% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 08, 2027 from Miami, Florida
Up to 2 deals
18-night panama canal cruise
$3,047
49% Off List
MSC Cruises – MSC Poesia
3.9 (29)
Departs Apr 06, 2028 from Miami, Florida
Up to 2 deals
32-night panama canal cruise
$2,629
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 02, 2026 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
42-night panama canal cruise
$4,499
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 02, 2026 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
14-night panama canal cruise
$6,119
Cunard – Queen Anne
5.0 (1)
Departs Apr 05, 2026 from Los Angeles, California
Up to 2 deals including an Avoya Exclusive
16-night panama canal cruise
$1,144
Carnival Cruises – Carnival Miracle
4.3 (63)
Departs Apr 11, 2026 from Tampa, Florida
Up to 5 deals including an Avoya Exclusive
16-night panama canal cruise
$1,059
Carnival Cruises – Carnival Spirit
4.4 (36)
Departs Apr 12, 2026 from Mobile, Alabama
Up to 6 deals including an Avoya Exclusive
30-night panama canal cruise
$3,399
Cunard – Queen Elizabeth
4.1 (35)
Departs Apr 14, 2026 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
28-night panama canal cruise
$2,283
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives
40-night panama canal cruise
$3,287
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 17, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives
33-night panama canal cruise
$2,517
Cunard – Queen Elizabeth
4.1 (35)
Departs Sep 24, 2026 from Seattle, Washington
Up to 3 deals including Avoya Exclusives

Panama Canal Cruises Overview

Almost 100 years after it was created in 1916, the Panama Canal not only serves as a connection between the Pacific and Atlantic Oceans, but also provides views of jungles, endangered species, pristine beaches, and more. Travelers have the chance to see exotic wildlife such as crocodiles, monkeys, sloths, and toucans while traversing the entire canal from Florida to the West coast, with stops in ports along the Caribbean, Mexican Riviera, and Central and South America.

The Panama Canal and its neighboring destinations have a variety of adventures for travelers. Surrounded by vast jungle, cruisers can trek through green, cloudy mountains while marveling at orchid gardens and distant volcanoes. The white sandy shores of several ports will entice cruisers to spend afternoons on the beach, after snorkeling, scuba diving, and kayaking through teal waters.

Passengers can explore the shipwreck of Antilla in Aruba; shop in Puerto Vallarta, Mexico; snorkel with the stingrays at the Stingray Sandbar in the Caymen Islands; enjoy the Aerial Tram ride through Costa Rica's rain forests; admire cliff divers in Acapulco; and more.

Travelers will want to pack a good pair of binoculars to use on the cruise deck when traveling through the tropical setting and fascinating sights of the Panama Canal. Cruises crossing the canal and stopping at nearby destinations provide the ultimate vacation filled with adventure, relaxation, and the opportunity to watch astounding views while lounging on deck or one's private balcony.

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