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Best South America Cruises

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63-night south america cruise
$42,299
Seabourn – Seabourn Quest
4.6 (43)
Departs Mar 04, 2028 from Buenos Aires, Argentina
Up to 1 deal
11-night south america cruise + tour
$12,323
Seabourn – Seabourn Venture
5.0 (2)
Departs Mar 11, 2028 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
11-night south america cruise + tour
$12,493
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Mar 15, 2028 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
26-night south america cruise + tour
$22,948
Seabourn – Seabourn Pursuit
5.0 (1)
Departs Mar 25, 2028 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
18-night south america cruise
$15,520
Silversea – Silver Whisper
4.6 (32)
Departs Feb 26, 2026 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$5,449
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 14, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
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AmaWaterways – AmaMelodia
Departs May 05, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
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AmaWaterways – AmaMelodia
Departs May 19, 2027 from Cartagena, Spain
8-night south america cruise
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Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Mar 14, 2026 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
14-night south america cruise
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Holland America – Oosterdam
4.2 (212)
Departs Mar 08, 2026 from Buenos Aires, Argentina
Up to 4 deals including Avoya Exclusives
17-night south america cruise
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Holland America – Oosterdam
4.2 (212)
Departs Mar 22, 2026 from San Antonio, Chile
Up to 4 deals including Avoya Exclusives
31-night south america cruise
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Holland America – Oosterdam
4.2 (212)
Departs Mar 08, 2026 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
1-night south america cruise
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MSC Cruises – MSC Preziosa
3.9 (7)
Departs Apr 02, 2026 from Santos, Brazil
4-night south america cruise
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MSC Cruises – MSC Divina
3.8 (92)
Departs Nov 12, 2026 from Salvador, Brazil
4-night south america cruise
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MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Nov 28, 2026 from Salvador, Brazil
1-night south america cruise
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MSC Cruises – MSC Virtuosa
5.0 (1)
Departs Dec 01, 2026 from Rio de Janeiro, Brazil
8-night south america cruise
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MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 06, 2026 from Rio de Janeiro, Brazil
9-night south america cruise
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MSC Cruises – MSC Splendida
4.7 (9)
Departs Dec 22, 2026 from Rio de Janeiro, Brazil
3-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 14, 2027 from Santos, Brazil
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 16, 2027 from Paranagua, Brazil
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 17, 2027 from ITAJAI
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 19, 2027 from Rio de Janeiro, Brazil
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 23, 2027 from Paranagua, Brazil
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 24, 2027 from ITAJAI
7-night south america cruise
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MSC Cruises – MSC Musica
3.5 (4)
Departs Jan 26, 2027 from Rio de Janeiro, Brazil

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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