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Best South America Cruises

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7-night south america cruise
$1,061
52% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 10, 2026 from Salvador, Brazil
7-night south america cruise
$1,490
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 11, 2026 from MACEIO
7-night south america cruise
$1,575
31% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 12, 2026 from Buenos Aires, Argentina
Up to 1 deal
4-night south america cruise
$803
49% Off List
MSC Cruises – MSC Sinfonia
4.0 (3)
Departs Mar 13, 2026 from Santos, Brazil
1-night south america cruise
$89
MSC Cruises – MSC Armonia
3.2 (19)
Departs Mar 14, 2026 from Rio de Janeiro, Brazil
7-night south america cruise
$1,120
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 14, 2026 from Santos, Brazil
8-night south america cruise
$2,494
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Mar 14, 2026 from Montevideo, Uruguay
Up to 1 deal
7-night south america cruise
$1,288
49% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 15, 2026 from Santos, Brazil
Up to 1 deal
8-night south america cruise
$1,820
49% Off List
MSC Cruises – MSC Fantasia
3.8 (12)
Departs Mar 15, 2026 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,252
45% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 17, 2026 from Salvador, Brazil
19-night south america cruise
$10,295
24% Off List
Viking Ocean Cruises – Viking Polaris
5.0 (1)
Departs Mar 17, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$1,609
48% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 18, 2026 from MACEIO
7-night south america cruise
$1,731
34% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 19, 2026 from Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,319
49% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 21, 2026 from Santos, Brazil
7-night south america cruise
$1,585
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 22, 2026 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,080
50% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 24, 2026 from Salvador, Brazil
7-night south america cruise
$1,621
48% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 25, 2026 from MACEIO
19-night south america cruise
$13,995
18% Off List
Viking Ocean Cruises – Viking Octantis
4.7 (9)
Departs Mar 26, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
7-night south america cruise
$1,197
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 28, 2026 from Santos, Brazil
4-night south america cruise
$947
50% Off List
MSC Cruises – MSC Preziosa
3.9 (7)
Departs Mar 29, 2026 from Santos, Brazil
Up to 1 deal
7-night south america cruise
$1,584
48% Off List
MSC Cruises – MSC Seaview
4.6 (5)
Departs Mar 31, 2026 from Salvador, Brazil
7-night south america cruise
$1,587
MSC Cruises – MSC Seaview
4.6 (5)
Departs Apr 01, 2026 from MACEIO
7-night south america cruise
$1,024
MSC Cruises – MSC Seaview
4.6 (5)
Departs Apr 04, 2026 from Santos, Brazil
16-night south america cruise
$8,754
Seabourn – Seabourn Venture
5.0 (2)
Departs Oct 13, 2026 from Bridgetown, Barbados
Up to 1 deal including an Avoya Exclusive
Secret Rate
12-night south america cruise
$9,995
9% Off List
Viking Ocean Cruises – Viking Polaris
5.0 (1)
Departs Nov 13, 2026 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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