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MSC Cruises to Mediterranean

Onboard MSC Cruises Mediterranean cruises, guests can relax in Italian style and comfort as they view colorful seaside villages and breathtaking vistas from their verandah. MSC Cruises to the Mediterranean stretch to far-reaching destinations including Alexandria, Casablanca, Dubrovnik, Istanbul, and Marseilles. A Mediterranean cruise with MSC Cruise Line is an exciting adventure through a destination rich with culture and beauty with the advantage of being in the cruise line’s own backyard.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Sinfonia itinerary map

7-night mediterranean cruise

Oceanview From

$1,218

56% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

Sep 01, 2026 View Other Dates →

Ports:

Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari → Santorini → Piraeus (Athens)

Departs Sep 01, 2026 from Piraeus (Athens), Greece

Up to 3 deals

Oceanview From

$1,218

56% Off List

List Price

$2,738

View Expanded Details

MSC Cruises MSC Divina itinerary map

7-night mediterranean cruise

Balcony From

$1,447

47% Off List

MSC Cruises – MSC Divina

3.892 Reviews

Date:

Sep 07, 2026 View Other Dates →

Ports:

Kusadasi → Marmaris → Naples → Rome (Civitavecchia) → Mykonos → Kusadasi

Departs Sep 07, 2026 from Kusadasi, Turkey

Up to 3 deals

Balcony From

$1,447

47% Off List

List Price

$2,744

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

7-night mediterranean cruise

Oceanview From

$1,116

58% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

Sep 12, 2026 View Other Dates →

Ports:

Bari → Santorini → Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari

Departs Sep 12, 2026 from Bari, Italy

Up to 3 deals

Oceanview From

$1,116

58% Off List

List Price

$2,634

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

7-night mediterranean cruise

Oceanview From

$1,312

47% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

Sep 19, 2026 View Other Dates →

Ports:

Bari → Santorini → Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari

Departs Sep 19, 2026 from Bari, Italy

Up to 3 deals

Oceanview From

$1,312

47% Off List

List Price

$2,494

View Expanded Details

MSC Cruises MSC Divina itinerary map

7-night mediterranean cruise

Balcony From

$1,287

50% Off List

MSC Cruises – MSC Divina

3.892 Reviews

Date:

Oct 05, 2026 View Other Dates →

Ports:

Kusadasi → Marmaris → Naples → Rome (Civitavecchia) → Mykonos → Kusadasi

Departs Oct 05, 2026 from Kusadasi, Turkey

Up to 4 deals

Balcony From

$1,287

50% Off List

List Price

$2,559

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

7-night mediterranean cruise

Inside From

$1,060

50% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

Oct 06, 2026 View Other Dates →

Ports:

Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari → Santorini → Piraeus (Athens)

Departs Oct 06, 2026 from Piraeus (Athens), Greece

Up to 4 deals

Inside From

$1,060

50% Off List

List Price

$2,122

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

7-night mediterranean cruise

Inside From

$1,020

51% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

Oct 13, 2026 View Other Dates →

Ports:

Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari → Santorini → Piraeus (Athens)

Departs Oct 13, 2026 from Piraeus (Athens), Greece

Up to 4 deals

Inside From

$1,020

51% Off List

List Price

$2,096

View Expanded Details

MSC Cruises MSC Musica itinerary map

7-night mediterranean cruise

Inside From

$890

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Apr 18, 2027 View Other Dates →

Ports:

Rome (Civitavecchia) → Palermo → Ibiza → Valencia → Marseille → Genoa → Rome (Civitavecchia)

Departs Apr 18, 2027 from Rome (Civitavecchia), Italy

Up to 4 deals

Inside From

$890

49% Off List

List Price

$1,746

View Expanded Details

MSC Cruises MSC Fantasia itinerary map

7-night mediterranean cruise

Balcony From

$1,200

43% Off List

MSC Cruises – MSC Fantasia

3.812 Reviews

Date:

Apr 25, 2027 View Other Dates →

Ports:

Cagliari → Rome (Civitavecchia) → Livorno → Cannes → Barcelona → Ibiza → Cagliari

Departs Apr 25, 2027 from Cagliari, Sardinia, Italy

Up to 4 deals

Balcony From

$1,200

43% Off List

List Price

$2,092

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night mediterranean cruise

Suite From

$3,577

48% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

Apr 25, 2027 View Other Dates →

Ports:

Livorno → Marseille → Barcelona → La Goulette → Palermo → Naples → Livorno

Departs Apr 25, 2027 from Livorno, Italy

Up to 4 deals

Suite From

$3,577

48% Off List

List Price

$6,867

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night mediterranean cruise

Inside From

$1,130

45% Off List

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Apr 26, 2027 View Other Dates →

Ports:

Marseille → Genoa → Naples → Palermo → Valletta → Barcelona → Marseille

Departs Apr 26, 2027 from Marseille, France

Up to 4 deals

Inside From

$1,130

45% Off List

List Price

$2,048

View Expanded Details

MSC Cruises MSC Orchestra itinerary map

7-night mediterranean cruise

Inside From

$1,027

50% Off List

MSC Cruises – MSC Orchestra

4.04 Reviews

Date:

Apr 27, 2027 View Other Dates →

Ports:

Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari → Santorini → Piraeus (Athens)

Departs Apr 27, 2027 from Piraeus (Athens), Greece

Up to 4 deals

Inside From

$1,027

50% Off List

List Price

$2,036

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night mediterranean cruise

Inside From

$1,138

44% Off List

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Apr 27, 2027

Ports:

Genoa → Naples → Palermo → Valletta → Barcelona → Marseille → Genoa

Departs Apr 27, 2027 from Genoa, Italy

Up to 4 deals

Inside From

$1,138

44% Off List

List Price

$2,016

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night mediterranean cruise

Inside From

$1,037

48% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

May 02, 2027 View Other Dates →

Ports:

Livorno → Marseille → Barcelona → La Goulette → Palermo → Naples → Livorno

Departs May 02, 2027 from Livorno, Italy

Up to 4 deals

Inside From

$1,037

48% Off List

List Price

$1,987

View Expanded Details

MSC Cruises MSC Orchestra itinerary map

7-night mediterranean cruise

Inside From

$1,087

50% Off List

MSC Cruises – MSC Orchestra

4.04 Reviews

Date:

May 04, 2027 View Other Dates →

Ports:

Piraeus (Athens) → Katakolon → Cefalonia/Argostoli Greece → Corfu → Bari → Santorini → Piraeus (Athens)

Departs May 04, 2027 from Piraeus (Athens), Greece

Up to 4 deals

Inside From

$1,087

50% Off List

List Price

$2,156

View Expanded Details

MSC Cruises MSC Musica itinerary map

7-night mediterranean cruise

Inside From

$891

48% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

May 08, 2027 View Other Dates →

Ports:

Genoa → Rome (Civitavecchia) → Palermo → Ibiza → Valencia → Marseille → Genoa

Departs May 08, 2027 from Genoa, Italy

Up to 4 deals

Inside From

$891

48% Off List

List Price

$1,705

View Expanded Details

MSC Cruises MSC Lirica itinerary map

7-night mediterranean cruise

Inside From

$1,045

46% Off List

MSC Cruises – MSC Lirica

4.36 Reviews

Date:

May 08, 2027 View Other Dates →

Ports:

Venice → Kotor → Mykonos → Syros Greece → Ancona → Venice

Departs May 08, 2027 from Venice, Italy

Up to 4 deals

Inside From

$1,045

46% Off List

List Price

$1,941

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

10-night mediterranean cruise

Inside From

$1,686

48% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

May 09, 2027 View Other Dates →

Ports:

Marseille → Malaga → Casablanca → Cadiz → Gibraltar → Alicante → Rome (Civitavecchia) → Genoa → Marseille

Departs May 09, 2027 from Marseille, France

Up to 4 deals

Inside From

$1,686

48% Off List

List Price

$3,249

View Expanded Details

MSC Cruises MSC World Europa itinerary map

7-night mediterranean cruise

Inside From

$1,312

48% Off List

MSC Cruises – MSC World Europa

2.03 Reviews

Date:

May 10, 2027 View Other Dates →

Ports:

Genoa → Florence (La Spezia) → Rome (Civitavecchia) → Palma de Mallorca → Barcelona → Marseille → Genoa

Departs May 10, 2027 from Genoa, Italy

Up to 4 deals

Inside From

$1,312

48% Off List

List Price

$2,513

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night mediterranean cruise

Inside From

$1,160

45% Off List

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

May 13, 2027 View Other Dates →

Ports:

Palermo → Valletta → Barcelona → Marseille → Genoa → Naples → Palermo

Departs May 13, 2027 from Palermo, Italy

Up to 4 deals

Inside From

$1,160

45% Off List

List Price

$2,108

View Expanded Details

MSC Cruises MSC World Europa itinerary map

7-night mediterranean cruise

Inside From

$1,266

49% Off List

MSC Cruises – MSC World Europa

2.03 Reviews

Date:

May 16, 2027 View Other Dates →

Ports:

Marseille → Genoa → Florence (La Spezia) → Rome (Civitavecchia) → Palma de Mallorca → Barcelona → Marseille

Departs May 16, 2027 from Marseille, France

Up to 4 deals

Inside From

$1,266

49% Off List

List Price

$2,496

View Expanded Details

MSC Cruises MSC World Asia itinerary map

7-night mediterranean cruise

Inside From

$1,371

48% Off List

MSC Cruises – MSC World Asia

Date:

May 16, 2027 View Other Dates →

Ports:

Genoa → Naples → Messina → Valletta → Barcelona → Marseille → Genoa

Departs May 16, 2027 from Genoa, Italy

Up to 3 deals

Inside From

$1,371

48% Off List

List Price

$2,655

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night mediterranean cruise

Inside From

$1,090

48% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

May 17, 2027 View Other Dates →

Ports:

Marseille → Barcelona → La Goulette → Palermo → Naples → Livorno → Marseille

Departs May 17, 2027 from Marseille, France

Up to 4 deals

Inside From

$1,090

48% Off List

List Price

$2,108

View Expanded Details

MSC Cruises MSC Sinfonia itinerary map

10-night mediterranean cruise

Inside From

$1,702

48% Off List

MSC Cruises – MSC Sinfonia

4.03 Reviews

Date:

May 18, 2027 View Other Dates →

Ports:

Genoa → Marseille → Malaga → Tangier → Portimao → Ceuta → Alicante → Rome (Civitavecchia) → Genoa

Departs May 18, 2027 from Genoa, Italy

Up to 4 deals

Inside From

$1,702

48% Off List

List Price

$3,266

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night mediterranean cruise

Inside From

$1,160

45% Off List

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

May 19, 2027 View Other Dates →

Ports:

Naples → Palermo → Valletta → Barcelona → Marseille → Genoa → Naples

Departs May 19, 2027 from Naples, Italy

Up to 4 deals

Inside From

$1,160

45% Off List

List Price

$2,108

View Expanded Details

Showing 1-25 of 4,281 results

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