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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
1-25 of
303
results
7-night south america cruise
$2,158
50% Off List
MSC Cruises –
MSC Seaview
Departs
Dec 19, 2025
from
Santos, Brazil
7-night south america cruise
$1,278
49% Off List
MSC Cruises –
MSC Armonia
Departs
Dec 20, 2025
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,478
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Dec 21, 2025
from
ITAJAI
7-night south america cruise
$1,642
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Dec 22, 2025
from
Santos, Brazil
7-night south america cruise
$2,293
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Dec 25, 2025
from
Rio de Janeiro, Brazil
8-night south america cruise
$2,407
50% Off List
MSC Cruises –
MSC Seaview
Departs
Dec 26, 2025
from
Santos, Brazil
8-night south america cruise
$1,815
48% Off List
MSC Cruises –
MSC Armonia
Departs
Dec 27, 2025
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$2,196
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Dec 28, 2025
from
ITAJAI
7-night south america cruise
$3,103
44% Off List
MSC Cruises –
MSC Sinfonia
Departs
Dec 29, 2025
from
Santos, Brazil
7-night south america cruise
$1,384
48% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 01, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,376
49% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 03, 2026
from
Santos, Brazil
7-night south america cruise
$841
MSC Cruises –
MSC Sinfonia
Departs
Jan 04, 2026
from
ITAJAI
6-night south america cruise
$1,008
52% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 04, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
8-night south america cruise
$2,223
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 04, 2026
from
Montevideo, Uruguay
Up to 1 deal
7-night south america cruise
$879
MSC Cruises –
MSC Sinfonia
Departs
Jan 05, 2026
from
Santos, Brazil
8-night south america cruise
$1,913
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 05, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,376
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 06, 2026
from
Salvador, Brazil
7-night south america cruise
$1,767
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 07, 2026
from
MACEIO
7-night south america cruise
$1,112
MSC Cruises –
MSC Sinfonia
Departs
Jan 08, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,136
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 10, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,313
49% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 10, 2026
from
Santos, Brazil
7-night south america cruise
$1,150
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 11, 2026
from
ITAJAI
7-night south america cruise
$1,239
47% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 12, 2026
from
Santos, Brazil
9-night south america cruise
$2,087
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 12, 2026
from
Montevideo, Uruguay
Up to 1 deal
7-night south america cruise
$1,175
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 13, 2026
from
MACEIO
Up to 1 deal