Menu
Call
No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! Learn More
Home
cruises
msc cruises
cruises to south america

MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

Showing 25 of 48 results
Roundtrip
7-Night South America Cruise
$669
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Jan 02, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
6-Night South America Cruise
$599
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Jan 09, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
8-Night South America Cruise
$769
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Jan 15, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
6-Night South America Cruise
$599
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Jan 23, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
8-Night South America Cruise
$719
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Jan 29, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
6-Night South America Cruise
$539
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Feb 06, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
8-Night South America Cruise
$719
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Feb 12, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
6-Night South America Cruise
$579
48% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Feb 20, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
7-Night South America Cruise
$859
49% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Feb 26, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
3-Night South America Cruise
$1,300
46% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Mar 05, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
3-Night South America Cruise
$279
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Mar 08, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
4-Night South America Cruise
$559
49% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Mar 21, 2022 from Santos, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
3-Night South America Cruise
$499
49% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Mar 28, 2022 from Santos, Brazil
Up to 3 deals
Roundtrip
4-Night South America Cruise
$379
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 03, 2022 from Santos, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
4-Night Mediterranean Cruise
$389
50% Off List
MSC Cruises – MSC Seaside
65 Reviews
Depart Apr 04, 2022 from Marseille, France
Up to 2 deals
24-Night Grand Voyage Cruise
$1,009
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 07, 2022 from Santos, Brazil
Up to 4 deals and Avoya Exclusives
19-Night Grand Voyage Cruise
$889
46% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 07, 2022 from Santos, Brazil
Up to 4 deals and Avoya Exclusives
15-Night Grand Voyage Cruise
$629
48% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 08, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
23-Night Grand Voyage Cruise
$969
50% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 08, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
19-Night Grand Voyage Cruise
$1,529
46% Off List
MSC Cruises – MSC Preziosa
6 Reviews
Depart Apr 08, 2022 from Rio de Janeiro, Brazil
Up to 4 deals and Avoya Exclusives
Roundtrip
7-Night South America Cruise
Call Us
MSC Cruises – MSC Sinfonia
3 Reviews
Depart Dec 11, 2021 from
Up to 4 deals and Avoya Exclusives
Roundtrip
6-Night South America Cruise
Call Us
MSC Cruises – MSC Sinfonia
3 Reviews
Depart Dec 18, 2021 from
Up to 4 deals and Avoya Exclusives
Roundtrip
7-Night South America Cruise
Call Us
MSC Cruises – MSC Sinfonia
3 Reviews
Depart Dec 24, 2021 from
Up to 4 deals and Avoya Exclusives
Roundtrip
9-Night South America Cruise
Call Us
MSC Cruises – MSC Sinfonia
3 Reviews
Depart Dec 31, 2021 from
Up to 4 deals and Avoya Exclusives
Roundtrip
7-Night South America Cruise
Call Us
MSC Cruises – MSC Splendida
8 Reviews
Depart Jan 02, 2022 from Santos, Brazil
Up to 4 deals and Avoya Exclusives
  1. 1
  2. 2
  3. Next
Don't Miss the Latest Deals!
Talk to a Vacation Planner
Avoya Logo
Why Choose Avoya?
About Avoya Travel
U.S. / Canada: 1-888-877-7042
UK: 0-800-098-8475
Australia: 1-800-651-320
International: 001-760-305-5070
Avoya Travel®
CST: 2085569-40
Fla. Seller of Travel Ref. No. ST36781
© Avoya Travel®. All Rights Reserved.
Avoya Travel Amex Logo
Avoya Travel® is an American Express Travel Representative.