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MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Musica itinerary map

4-night south america cruise

Inside From

$536

50% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Nov 16, 2026

Ports:

Santos → Ilha Grande Brazil → Ilhabela Brazil → Santos

Departs Nov 16, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$536

50% Off List

List Price

$1,064

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Balcony From

$768

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Nov 20, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Nov 20, 2026 from Santos, Brazil

Up to 4 deals

Balcony From

$768

49% Off List

List Price

$1,502

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Oceanview From

$468

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Nov 23, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Nov 23, 2026 from Santos, Brazil

Up to 4 deals

Oceanview From

$468

49% Off List

List Price

$922

View Expanded Details

MSC Cruises MSC Musica itinerary map

4-night south america cruise

Inside From

$536

50% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Nov 26, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Ilha Grande Brazil → Santos

Departs Nov 26, 2026 from Santos, Brazil

Up to 3 deals

Inside From

$536

50% Off List

List Price

$1,064

View Expanded Details

MSC Cruises MSC Seaview itinerary map

3-night south america cruise

Inside From

$559

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Nov 29, 2026

Ports:

Santos → Armacao dos Buzios → Santos

Departs Nov 29, 2026 from Santos, Brazil

Up to 3 deals

Inside From

$559

View Expanded Details

MSC Cruises MSC Divina itinerary map

4-night south america cruise

Inside From

$599

49% Off List

MSC Cruises – MSC Divina

3.892 Reviews

Date:

Nov 29, 2026

Ports:

Santos → Ilha Grande Brazil → Armacao dos Buzios → Santos

Departs Nov 29, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$599

49% Off List

List Price

$1,184

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Inside From

$409

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Nov 30, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Nov 30, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$409

49% Off List

List Price

$808

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Inside From

$398

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Dec 03, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Dec 03, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$398

49% Off List

List Price

$782

View Expanded Details

MSC Cruises MSC Splendida itinerary map

8-night south america cruise

Inside From

$1,817

34% Off List

MSC Cruises – MSC Splendida

4.79 Reviews

Date:

Dec 03, 2026 View Other Dates →

Ports:

Buenos Aires → Rio de Janeiro → Ilhabela Brazil → Camboriu Brazil → Punta del Este → Buenos Aires

Departs Dec 03, 2026 from Buenos Aires, Argentina

Up to 4 deals

Inside From

$1,817

34% Off List

List Price

$2,774

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night south america cruise

Inside From

$1,079

48% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

Dec 05, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Salvador → Maceio Brazil → Santos

Departs Dec 05, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$1,079

48% Off List

List Price

$2,084

View Expanded Details

MSC Cruises MSC Seaview itinerary map

8-night south america cruise

Inside From

$1,119

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Dec 05, 2026

Ports:

Santos → Camboriu Brazil → Punta del Este → Montevideo → Buenos Aires → Santos

Departs Dec 05, 2026 from Santos, Brazil

Up to 3 deals

Inside From

$1,119

View Expanded Details

MSC Cruises MSC Musica itinerary map

4-night south america cruise

Inside From

$525

50% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Dec 06, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Ilha Grande Brazil → Santos

Departs Dec 06, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$525

50% Off List

List Price

$1,044

View Expanded Details

MSC Cruises MSC Seaview itinerary map

8-night south america cruise

Inside From

$1,109

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Dec 06, 2026

Ports:

Camboriu Brazil → Punta del Este → Montevideo → Buenos Aires → Santos

Departs Dec 06, 2026 from Camboriu

Up to 3 deals

Inside From

$1,109

View Expanded Details

MSC Cruises MSC Splendida itinerary map

8-night south america cruise

Balcony From

$1,471

50% Off List

MSC Cruises – MSC Splendida

4.79 Reviews

Date:

Dec 06, 2026 View Other Dates →

Ports:

Rio de Janeiro → Ilhabela Brazil → Camboriu Brazil → Punta del Este → Buenos Aires → Rio de Janeiro

Departs Dec 06, 2026 from Rio de Janeiro, Brazil

Up to 4 deals

Balcony From

$1,471

50% Off List

List Price

$2,919

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Inside From

$468

40% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Dec 10, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Dec 10, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$468

40% Off List

List Price

$782

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night south america cruise

Inside From

$1,397

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Dec 10, 2026 View Other Dates →

Ports:

Buenos Aires → Santos → Camboriu Brazil → Punta del Este → Buenos Aires

Departs Dec 10, 2026 from Buenos Aires, Argentina

Up to 3 deals

Inside From

$1,397

View Expanded Details

MSC Cruises MSC Splendida itinerary map

8-night south america cruise

Oceanview From

$2,097

35% Off List

MSC Cruises – MSC Splendida

4.79 Reviews

Date:

Dec 11, 2026 View Other Dates →

Ports:

Buenos Aires → Rio de Janeiro → Ilhabela Brazil → Camboriu Brazil → Punta del Este → Buenos Aires

Departs Dec 11, 2026 from Buenos Aires, Argentina

Up to 4 deals

Oceanview From

$2,097

35% Off List

List Price

$3,236

View Expanded Details

MSC Cruises MSC Musica itinerary map

4-night south america cruise

Inside From

$535

50% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Dec 13, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Ilha Grande Brazil → Santos

Departs Dec 13, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$535

50% Off List

List Price

$1,064

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night south america cruise

Inside From

$1,379

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Dec 13, 2026 View Other Dates →

Ports:

Santos → Camboriu Brazil → Punta del Este → Buenos Aires → Santos

Departs Dec 13, 2026 from Santos, Brazil

Up to 3 deals

Inside From

$1,379

View Expanded Details

MSC Cruises MSC Seaview itinerary map

7-night south america cruise

Inside From

$1,359

MSC Cruises – MSC Seaview

4.65 Reviews

Date:

Dec 14, 2026 View Other Dates →

Ports:

Camboriu Brazil → Punta del Este → Buenos Aires → Santos

Departs Dec 14, 2026 from Camboriu

Up to 3 deals

Inside From

$1,359

View Expanded Details

MSC Cruises MSC Splendida itinerary map

8-night south america cruise

Balcony From

$1,611

50% Off List

MSC Cruises – MSC Splendida

4.79 Reviews

Date:

Dec 14, 2026 View Other Dates →

Ports:

Rio de Janeiro → Ilhabela Brazil → Camboriu Brazil → Punta del Este → Buenos Aires → Rio de Janeiro

Departs Dec 14, 2026 from Rio de Janeiro, Brazil

Up to 4 deals

Balcony From

$1,611

50% Off List

List Price

$3,199

View Expanded Details

MSC Cruises MSC Divina itinerary map

3-night south america cruise

Inside From

$509

49% Off List

MSC Cruises – MSC Divina

3.892 Reviews

Date:

Dec 15, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Dec 15, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$509

49% Off List

List Price

$990

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night south america cruise

Balcony From

$1,186

49% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

Dec 15, 2026 View Other Dates →

Ports:

Salvador → Maceio Brazil → Santos → Armacao dos Buzios → Salvador

Departs Dec 15, 2026 from Salvador, Brazil

Up to 4 deals

Balcony From

$1,186

49% Off List

List Price

$2,325

View Expanded Details

MSC Cruises MSC Virtuosa itinerary map

7-night south america cruise

Inside From

$1,056

48% Off List

MSC Cruises – MSC Virtuosa

5.01 Reviews

Date:

Dec 16, 2026 View Other Dates →

Ports:

Maceio Brazil → Santos → Armacao dos Buzios → Salvador

Departs Dec 16, 2026 from Maceio

Up to 4 deals

Inside From

$1,056

48% Off List

List Price

$2,019

View Expanded Details

MSC Cruises MSC Musica itinerary map

3-night south america cruise

Inside From

$408

49% Off List

MSC Cruises – MSC Musica

3.54 Reviews

Date:

Dec 17, 2026 View Other Dates →

Ports:

Santos → Armacao dos Buzios → Santos

Departs Dec 17, 2026 from Santos, Brazil

Up to 4 deals

Inside From

$408

49% Off List

List Price

$802

View Expanded Details

Showing 1-25 of 296 results

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