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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
26-50 of
312
results
8-night south america cruise
$1,913
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 05, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,376
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 06, 2026
from
Salvador, Brazil
7-night south america cruise
$1,767
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 07, 2026
from
MACEIO
7-night south america cruise
$1,112
MSC Cruises –
MSC Sinfonia
Departs
Jan 08, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,136
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 10, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,313
49% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 10, 2026
from
Santos, Brazil
7-night south america cruise
$1,150
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 11, 2026
from
ITAJAI
7-night south america cruise
$1,239
47% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 12, 2026
from
Santos, Brazil
9-night south america cruise
$2,087
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 12, 2026
from
Montevideo, Uruguay
Up to 1 deal
7-night south america cruise
$1,175
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 13, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$1,339
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 13, 2026
from
Salvador, Brazil
9-night south america cruise
$2,175
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 13, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,221
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 14, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,717
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 14, 2026
from
MACEIO
7-night south america cruise
$1,381
47% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 15, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,247
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 17, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,275
49% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 17, 2026
from
Santos, Brazil
8-night south america cruise
$1,749
50% Off List
MSC Cruises –
MSC Preziosa
Departs
Jan 17, 2026
from
Santos, Brazil
Up to 1 deal
7-night south america cruise
$879
MSC Cruises –
MSC Sinfonia
Departs
Jan 18, 2026
from
ITAJAI
7-night south america cruise
$1,148
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 19, 2026
from
Santos, Brazil
7-night south america cruise
$1,023
MSC Cruises –
MSC Seaview
Departs
Jan 20, 2026
from
Salvador, Brazil
7-night south america cruise
$1,242
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 20, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$1,175
49% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 21, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,175
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 21, 2026
from
MACEIO
8-night south america cruise
$1,834
50% Off List
MSC Cruises –
MSC Preziosa
Departs
Jan 21, 2026
from
Buenos Aires, Argentina
Up to 1 deal