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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
51-75 of
312
results
8-night south america cruise
$1,910
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 21, 2026
from
Montevideo, Uruguay
Up to 1 deal
8-night south america cruise
$1,913
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 22, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,055
49% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 24, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,275
52% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 24, 2026
from
Santos, Brazil
7-night south america cruise
$1,443
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Jan 25, 2026
from
Santos, Brazil
Up to 1 deal
4-night south america cruise
$859
47% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 26, 2026
from
Santos, Brazil
7-night south america cruise
$1,119
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 27, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$1,175
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 27, 2026
from
Salvador, Brazil
7-night south america cruise
$1,119
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 28, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,250
50% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 28, 2026
from
MACEIO
7-night south america cruise
$1,415
28% Off List
MSC Cruises –
MSC Preziosa
Departs
Jan 29, 2026
from
Buenos Aires, Argentina
Up to 1 deal
9-night south america cruise
$2,501
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 29, 2026
from
Montevideo, Uruguay
Up to 1 deal
4-night south america cruise
$776
49% Off List
MSC Cruises –
MSC Sinfonia
Departs
Jan 30, 2026
from
Santos, Brazil
9-night south america cruise
$1,988
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Jan 30, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$1,181
49% Off List
MSC Cruises –
MSC Seaview
Departs
Jan 31, 2026
from
Santos, Brazil
7-night south america cruise
$1,192
50% Off List
MSC Cruises –
MSC Armonia
Departs
Jan 31, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,092
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Feb 01, 2026
from
Santos, Brazil
Up to 1 deal
3-night south america cruise
$658
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 03, 2026
from
Santos, Brazil
7-night south america cruise
$1,087
50% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 03, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$1,238
50% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 03, 2026
from
Salvador, Brazil
7-night south america cruise
$1,120
49% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 04, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,477
50% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 04, 2026
from
MACEIO
7-night south america cruise
$919
61% Off List
MSC Cruises –
MSC Preziosa
Departs
Feb 05, 2026
from
Buenos Aires, Argentina
Up to 1 deal
4-night south america cruise
$748
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 06, 2026
from
Santos, Brazil
7-night south america cruise
$1,058
50% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 07, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal