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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
Click Here!
MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
101-125 of
331
results
9-night south america cruise
$1,988
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Feb 17, 2026
from
Buenos Aires, Argentina
Up to 1 deal
7-night south america cruise
$995
54% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 18, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,061
50% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 18, 2026
from
MACEIO
4-night south america cruise
$748
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 20, 2026
from
Santos, Brazil
7-night south america cruise
$1,036
49% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 21, 2026
from
Santos, Brazil
7-night south america cruise
$1,058
51% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 21, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,113
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Feb 22, 2026
from
Santos, Brazil
Up to 1 deal
3-night south america cruise
$646
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 24, 2026
from
Santos, Brazil
7-night south america cruise
$1,114
50% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 24, 2026
from
Salvador, Brazil
7-night south america cruise
$1,121
49% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 24, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$965
49% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 25, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,132
50% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 25, 2026
from
MACEIO
8-night south america cruise
$1,349
50% Off List
MSC Cruises –
MSC Preziosa
Departs
Feb 25, 2026
from
Buenos Aires, Argentina
8-night south america cruise
$2,269
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Feb 25, 2026
from
Montevideo, Uruguay
Up to 1 deal
8-night south america cruise
$1,907
49% Off List
MSC Cruises –
MSC Fantasia
Departs
Feb 26, 2026
from
Buenos Aires, Argentina
Up to 1 deal
4-night south america cruise
$712
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Feb 27, 2026
from
Santos, Brazil
7-night south america cruise
$1,019
48% Off List
MSC Cruises –
MSC Armonia
Departs
Feb 28, 2026
from
Rio de Janeiro, Brazil
Up to 1 deal
7-night south america cruise
$1,086
49% Off List
MSC Cruises –
MSC Seaview
Departs
Feb 28, 2026
from
Santos, Brazil
7-night south america cruise
$1,028
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 01, 2026
from
Santos, Brazil
Up to 1 deal
3-night south america cruise
$651
50% Off List
MSC Cruises –
MSC Sinfonia
Departs
Mar 03, 2026
from
Santos, Brazil
7-night south america cruise
$1,099
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 03, 2026
from
Salvador, Brazil
7-night south america cruise
$1,154
41% Off List
MSC Cruises –
MSC Armonia
Departs
Mar 03, 2026
from
MACEIO
Up to 1 deal
7-night south america cruise
$915
49% Off List
MSC Cruises –
MSC Armonia
Departs
Mar 04, 2026
from
Salvador, Brazil
Up to 1 deal
7-night south america cruise
$1,490
50% Off List
MSC Cruises –
MSC Seaview
Departs
Mar 04, 2026
from
MACEIO
7-night south america cruise
$1,479
49% Off List
MSC Cruises –
MSC Preziosa
Departs
Mar 05, 2026
from
Buenos Aires, Argentina
Up to 1 deal