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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
151-175 of
331
results
7-night south america cruise
$1,052
50% Off List
MSC Cruises –
MSC Seaview
Departs
Apr 01, 2026
from
MACEIO
7-night south america cruise
$1,024
MSC Cruises –
MSC Seaview
Departs
Apr 04, 2026
from
Santos, Brazil
4-night south america cruise
$475
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 12, 2026
from
Santos, Brazil
4-night south america cruise
$499
48% Off List
MSC Cruises –
MSC Musica
Departs
Nov 16, 2026
from
Santos, Brazil
3-night south america cruise
$403
50% Off List
MSC Cruises –
MSC Musica
Departs
Nov 20, 2026
from
Santos, Brazil
3-night south america cruise
$389
48% Off List
MSC Cruises –
MSC Musica
Departs
Nov 23, 2026
from
Santos, Brazil
4-night south america cruise
$499
48% Off List
MSC Cruises –
MSC Musica
Departs
Nov 26, 2026
from
Santos, Brazil
3-night south america cruise
$389
48% Off List
MSC Cruises –
MSC Musica
Departs
Nov 30, 2026
from
Santos, Brazil
3-night south america cruise
$449
48% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 02, 2026
from
Santos, Brazil
3-night south america cruise
$363
50% Off List
MSC Cruises –
MSC Musica
Departs
Dec 03, 2026
from
Santos, Brazil
8-night south america cruise
$919
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 03, 2026
from
Buenos Aires, Argentina
3-night south america cruise
$439
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
4-night south america cruise
$569
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
7-night south america cruise
$849
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 05, 2026
from
Santos, Brazil
3-night south america cruise
$319
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
4-night south america cruise
$499
48% Off List
MSC Cruises –
MSC Musica
Departs
Dec 06, 2026
from
Santos, Brazil
6-night south america cruise
$679
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
7-night south america cruise
$839
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 06, 2026
from
Santos, Brazil
7-night south america cruise
$869
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 08, 2026
from
Salvador, Brazil
6-night south america cruise
$749
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 09, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$869
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 09, 2026
from
MACEIO
3-night south america cruise
$389
48% Off List
MSC Cruises –
MSC Musica
Departs
Dec 10, 2026
from
Santos, Brazil
8-night south america cruise
$849
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 10, 2026
from
Montevideo, Uruguay
8-night south america cruise
$919
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 11, 2026
from
Buenos Aires, Argentina
7-night south america cruise
$839
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 12, 2026
from
Paranagua, Brazil