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No Avoya Fees on Cruises or Tours. Book, change, or cancel without paying any Avoya fees. Plus, our Low Price Guarantee! No Avoya Fees on Cruises or Tours.
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MSC Cruises to South America
MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.
Showing
176-200 of
331
results
7-night south america cruise
$849
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 12, 2026
from
Santos, Brazil
4-night south america cruise
$499
48% Off List
MSC Cruises –
MSC Musica
Departs
Dec 13, 2026
from
Santos, Brazil
7-night south america cruise
$839
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 13, 2026
from
ITAJAI
7-night south america cruise
$839
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 15, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$869
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 15, 2026
from
Salvador, Brazil
7-night south america cruise
$869
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 16, 2026
from
MACEIO
3-night south america cruise
$389
48% Off List
MSC Cruises –
MSC Musica
Departs
Dec 17, 2026
from
Santos, Brazil
8-night south america cruise
$1,049
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 18, 2026
from
Montevideo, Uruguay
7-night south america cruise
$1,099
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 19, 2026
from
Paranagua, Brazil
8-night south america cruise
$1,119
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 19, 2026
from
Buenos Aires, Argentina
7-night south america cruise
$1,139
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 19, 2026
from
Santos, Brazil
7-night south america cruise
$1,099
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 20, 2026
from
ITAJAI
8-night south america cruise
$1,229
49% Off List
MSC Cruises –
MSC Musica
Departs
Dec 20, 2026
from
Santos, Brazil
7-night south america cruise
$1,099
49% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 22, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,159
49% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 22, 2026
from
Salvador, Brazil
3-night south america cruise
$359
MSC Cruises –
MSC Virtuosa
Departs
Dec 23, 2026
from
MACEIO
7-night south america cruise
$1,549
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 26, 2026
from
Paranagua, Brazil
7-night south america cruise
$1,599
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 26, 2026
from
Santos, Brazil
9-night south america cruise
$1,629
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 26, 2026
from
Montevideo, Uruguay
7-night south america cruise
$1,549
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 27, 2026
from
ITAJAI
9-night south america cruise
$1,730
49% Off List
MSC Cruises –
MSC Splendida
Departs
Dec 27, 2026
from
Buenos Aires, Argentina
9-night south america cruise
$2,039
49% Off List
MSC Cruises –
MSC Musica
Departs
Dec 28, 2026
from
Santos, Brazil
7-night south america cruise
$1,549
50% Off List
MSC Cruises –
MSC Lirica
Departs
Dec 29, 2026
from
Rio de Janeiro, Brazil
7-night south america cruise
$1,594
50% Off List
MSC Cruises –
MSC Virtuosa
Departs
Dec 29, 2026
from
Salvador, Brazil
4-night south america cruise
$569
MSC Cruises –
MSC Virtuosa
Departs
Jan 02, 2027
from
Santos, Brazil