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Best Cruises out of San Diego, California
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7-night mexico cruise
$911
4% Off
Royal Caribbean –
Serenade of the Seas
Departs
Nov 22, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$437
5% Off
Royal Caribbean –
Serenade of the Seas
Departs
Oct 15, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$1,091
6% Off
Royal Caribbean –
Serenade of the Seas
Departs
Dec 27, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$789
Royal Caribbean –
Serenade of the Seas
Departs
Apr 25, 2027
from
San Diego, California
Up to 3 deals
including an Avoya Exclusive
Avoya Exclusive Rate
7-night mexico cruise
$621
Royal Caribbean –
Serenade of the Seas
Departs
Oct 04, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$599
Royal Caribbean –
Serenade of the Seas
Departs
Oct 18, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$657
Royal Caribbean –
Serenade of the Seas
Departs
Oct 25, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
2-night mexico cruise
$329
Royal Caribbean –
Serenade of the Seas
Departs
Oct 02, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
4-night mexico cruise
$485
17% Off
Royal Caribbean –
Serenade of the Seas
Departs
Oct 11, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$601
Royal Caribbean –
Serenade of the Seas
Departs
Nov 01, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$629
Royal Caribbean –
Serenade of the Seas
Departs
Nov 08, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$599
Royal Caribbean –
Serenade of the Seas
Departs
Nov 15, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$419
Royal Caribbean –
Serenade of the Seas
Departs
Nov 29, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
3-night mexico cruise
$364
Royal Caribbean –
Serenade of the Seas
Departs
Dec 03, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$399
Royal Caribbean –
Serenade of the Seas
Departs
Dec 06, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
3-night mexico cruise
$349
Royal Caribbean –
Serenade of the Seas
Departs
Dec 10, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$627
Royal Caribbean –
Serenade of the Seas
Departs
Dec 13, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$953
Royal Caribbean –
Serenade of the Seas
Departs
Dec 20, 2026
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
7-night mexico cruise
$631
Royal Caribbean –
Serenade of the Seas
Departs
Jan 03, 2027
from
San Diego, California
Up to 3 deals
including Avoya Exclusives
4-night mexico cruise
$452
Royal Caribbean –
Serenade of the Seas
Departs
Jan 10, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
3-night mexico cruise
$404
Royal Caribbean –
Serenade of the Seas
Departs
Jan 14, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$433
Royal Caribbean –
Serenade of the Seas
Departs
Jan 17, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
3-night mexico cruise
$384
Royal Caribbean –
Serenade of the Seas
Departs
Jan 21, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
4-night mexico cruise
$452
Royal Caribbean –
Serenade of the Seas
Departs
Jan 24, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
7-night mexico cruise
$671
Royal Caribbean –
Serenade of the Seas
Departs
Jan 28, 2027
from
San Diego, California
Up to 4 deals
including Avoya Exclusives
Avoya Exclusive Rate
Cruises from San Diego, California
Cruises from San Diego are a wonderful option for guests departing from the West Coast. Offering varied itineraries for cruisers both regionally and out-of-state, visitors sailings from this North America Departure Port are also convenient – as before or after your San Diego cruise, you can explore the city’s unique attractions. Popular destinations that you can visit on cruises from San Diego include Mexico, Hawaii, and more!