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MSC Cruises to Caribbean

Onboard an MSC Cruises Caribbean vacation, guests will enjoy all that the Caribbean has to offer with a cruise line that is focused on providing family fun with a distinctly Italian elegance. MSC Cruise Line features the MSC Poesia in the Caribbean, with cruise vacation itineraries that include over 23 destinations and countless unforgettable shore excursions. On all MSC Cruises to the Caribbean, kids sail free, ensuring that each of MSC Cruises’ Caribbean cruises are a great value and a perfect choice for family getaways.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,490

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 23, 2028 View Other Dates →

Ports:

Departs Oct 23, 2028 from La Romana, Dominican Republic

Up to 1 deal

Inside From

$1,490

49% Off List

List Price

$2,910

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,428

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 26, 2028 View Other Dates →

Ports:

Departs Oct 26, 2028 from Bridgetown, Barbados

Up to 1 deal

Inside From

$1,428

49% Off List

List Price

$2,786

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$729

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 27, 2028 View Other Dates →

Ports:

Departs Oct 27, 2028 from Fort de France, Martinique

Up to 2 deals

Inside From

$729

49% Off List

List Price

$1,429

View Expanded Details

MSC Cruises MSC World Atlantic itinerary map

14-night caribbean cruise

Inside From

$1,662

48% Off List

MSC Cruises – MSC World Atlantic

Date:

Oct 28, 2028 View Other Dates →

Ports:

Departs Oct 28, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$1,662

48% Off List

List Price

$3,180

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$739

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 30, 2028 View Other Dates →

Ports:

Departs Oct 30, 2028 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$739

49% Off List

List Price

$1,449

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,428

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 30, 2028 View Other Dates →

Ports:

Departs Oct 30, 2028 from La Romana, Dominican Republic

Up to 1 deal

Inside From

$1,428

49% Off List

List Price

$2,786

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$718

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Nov 03, 2028 View Other Dates →

Ports:

Fort de France → Saint Johns → La Romana → Catalina Island Dominican Republic → Bridgetown → Fort de France

Departs Nov 03, 2028 from Fort de France, Martinique

Up to 2 deals

Inside From

$718

49% Off List

List Price

$1,407

View Expanded Details

MSC Cruises MSC Seascape itinerary map

7-night caribbean cruise

Inside From

$665

49% Off List

MSC Cruises – MSC Seascape

4.120 Reviews

Date:

Nov 05, 2028 View Other Dates →

Ports:

Galveston → Costa Maya → Roatan → Cozumel → Galveston

Departs Nov 05, 2028 from Galveston, Texas

Up to 2 deals

Inside From

$665

49% Off List

List Price

$1,315

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$708

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Nov 06, 2028 View Other Dates →

Ports:

Departs Nov 06, 2028 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$708

49% Off List

List Price

$1,387

View Expanded Details

MSC Cruises MSC World Europa itinerary map

7-night caribbean cruise

Inside From

$1,125

MSC Cruises – MSC World Europa

2.03 Reviews

Date:

Dec 06, 2026 View Other Dates →

Ports:

Departs Dec 06, 2026 from Pointe-a-Pitre, Guadeloupe

Up to 2 deals

Inside From

$1,125

View Expanded Details

MSC Cruises MSC Seashore itinerary map

10-night caribbean cruise

Inside From

$1,021

59% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Dec 17, 2026

Ports:

Departs Dec 17, 2026 from Port Canaveral, Florida

Up to 1 deal

Inside From

$1,021

59% Off List

List Price

$2,502

View Expanded Details

MSC Cruises MSC Seashore itinerary map

11-night caribbean cruise

Inside From

$1,083

61% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Dec 27, 2026

Ports:

Departs Dec 27, 2026 from Port Canaveral, Florida

Up to 1 deal

Inside From

$1,083

61% Off List

List Price

$2,772

View Expanded Details

MSC Cruises MSC Seashore itinerary map

4-night caribbean cruise

Inside From

$284

46% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Jan 03, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Jan 03, 2027 from Port Canaveral, Florida

Up to 1 deal

Inside From

$284

46% Off List

List Price

$524

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Oceanview From

$259

54% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Jan 08, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Jan 08, 2027 from Miami, Florida

Up to 3 deals

Oceanview From

$259

54% Off List

List Price

$563

View Expanded Details

MSC Cruises MSC Seashore itinerary map

4-night caribbean cruise

Inside From

$223

62% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Jan 10, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Jan 10, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$223

62% Off List

List Price

$582

View Expanded Details

MSC Cruises MSC Seashore itinerary map

4-night caribbean cruise

Inside From

$280

52% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Jan 17, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Jan 17, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$280

52% Off List

List Price

$584

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Inside From

$223

54% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Jan 22, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Jan 22, 2027 from Miami, Florida

Up to 3 deals

Inside From

$223

54% Off List

List Price

$483

View Expanded Details

MSC Cruises MSC World America itinerary map

7-night caribbean cruise

Inside From

$576

58% Off List

MSC Cruises – MSC World America

Date:

Jan 23, 2027 View Other Dates →

Ports:

Miami → Puerto Plata → San Juan → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Jan 23, 2027 from Miami, Florida

Up to 2 deals

Inside From

$576

58% Off List

List Price

$1,367

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

14-night caribbean cruise

Inside From

$755

62% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Jan 23, 2027 View Other Dates →

Ports:

Departs Jan 23, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$755

62% Off List

List Price

$2,012

View Expanded Details

MSC Cruises MSC Seashore itinerary map

4-night caribbean cruise

Inside From

$228

61% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Jan 24, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Jan 24, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$228

61% Off List

List Price

$584

View Expanded Details

MSC Cruises MSC World America itinerary map

14-night caribbean cruise

Inside From

$1,642

41% Off List

MSC Cruises – MSC World America

Date:

Jan 30, 2027 View Other Dates →

Ports:

Departs Jan 30, 2027 from Miami, Florida

Up to 2 deals

Inside From

$1,642

41% Off List

List Price

$2,766

View Expanded Details

MSC Cruises MSC Seashore itinerary map

3-night caribbean cruise

Inside From

$303

50% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Feb 11, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Feb 11, 2027 from Port Canaveral, Florida

Up to 1 deal

Inside From

$303

50% Off List

List Price

$603

View Expanded Details

MSC Cruises MSC World America itinerary map

14-night caribbean cruise

Inside From

$1,581

48% Off List

MSC Cruises – MSC World America

Date:

Feb 13, 2027 View Other Dates →

Ports:

Departs Feb 13, 2027 from Miami, Florida

Up to 2 deals

Inside From

$1,581

48% Off List

List Price

$3,046

View Expanded Details

MSC Cruises MSC Seashore itinerary map

4-night caribbean cruise

Inside From

$403

39% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Feb 14, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Feb 14, 2027 from Port Canaveral, Florida

Up to 1 deal

Inside From

$403

39% Off List

List Price

$664

View Expanded Details

MSC Cruises MSC Seashore itinerary map

3-night caribbean cruise

Inside From

$290

60% Off List

MSC Cruises – MSC Seashore

4.125 Reviews

Date:

Mar 18, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs Mar 18, 2027 from Port Canaveral, Florida

Up to 1 deal

Inside From

$290

60% Off List

List Price

$723

View Expanded Details

Showing 951-975 of 1,181 results

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