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MSC Cruises to Caribbean

Onboard an MSC Cruises Caribbean vacation, guests will enjoy all that the Caribbean has to offer with a cruise line that is focused on providing family fun with a distinctly Italian elegance. MSC Cruise Line features the MSC Poesia in the Caribbean, with cruise vacation itineraries that include over 23 destinations and countless unforgettable shore excursions. On all MSC Cruises to the Caribbean, kids sail free, ensuring that each of MSC Cruises’ Caribbean cruises are a great value and a perfect choice for family getaways.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Balcony From

$339

47% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Dec 11, 2026 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Dec 11, 2026 from Miami, Florida

Up to 2 deals

Balcony From

$339

47% Off List

List Price

$641

View Expanded Details

MSC Cruises MSC Poesia itinerary map

10-night caribbean cruise

Inside From

$536

72% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Dec 13, 2026

Ports:

Miami → George Town Cayman Islands → Ocho Rios → Curacao → Bonaire → Oranjestad → Miami

Departs Dec 13, 2026 from Miami, Florida

Up to 3 deals

Inside From

$536

72% Off List

List Price

$1,936

View Expanded Details

MSC Cruises MSC World Europa itinerary map

14-night caribbean cruise

Inside From

$1,958

MSC Cruises – MSC World Europa

2.03 Reviews

Date:

Dec 15, 2026

Ports:

Departs Dec 15, 2026 from Bridgetown, Barbados

Up to 2 deals

Inside From

$1,958

View Expanded Details

MSC Cruises MSC Poesia itinerary map

10-night caribbean cruise

Inside From

$1,146

41% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Jan 14, 2027

Ports:

Miami → Curacao → Oranjestad → Ocho Rios → George Town Cayman Islands → Cozumel → Miami

Departs Jan 14, 2027 from Miami, Florida

Up to 3 deals

Inside From

$1,146

41% Off List

List Price

$1,946

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

6-night caribbean cruise

Inside From

$350

67% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 21, 2027

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Grand Turk → Miami

Departs Feb 21, 2027 from Miami, Florida

Up to 4 deals

Inside From

$350

67% Off List

List Price

$1,054

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

8-night caribbean cruise

Inside From

$700

48% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 27, 2027

Ports:

Miami → Saint Maarten (Phillipsburg) → Saint Johns → Charlotte Amalie → Amber Cove Dominican Republic → Miami

Departs Feb 27, 2027 from Miami, Florida

Up to 4 deals

Inside From

$700

48% Off List

List Price

$1,346

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$659

52% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Mar 01, 2027 View Other Dates →

Ports:

Departs Mar 01, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$659

52% Off List

List Price

$1,385

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

6-night caribbean cruise

Inside From

$352

70% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Mar 07, 2027 View Other Dates →

Ports:

Miami → Grand Turk → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs Mar 07, 2027 from Miami, Florida

Up to 3 deals

Inside From

$352

70% Off List

List Price

$1,174

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$1,020

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Mar 15, 2027 View Other Dates →

Ports:

Departs Mar 15, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$1,020

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$769

52% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Mar 29, 2027 View Other Dates →

Ports:

Departs Mar 29, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$769

52% Off List

List Price

$1,601

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$929

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 12, 2027 View Other Dates →

Ports:

Departs Apr 12, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$929

49% Off List

List Price

$1,818

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$977

47% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 19, 2027 View Other Dates →

Ports:

Departs Apr 19, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$977

47% Off List

List Price

$1,840

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$987

47% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 26, 2027 View Other Dates →

Ports:

Departs Apr 26, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$987

47% Off List

List Price

$1,847

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$697

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 10, 2027 View Other Dates →

Ports:

Departs May 10, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$697

54% Off List

List Price

$1,518

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$749

50% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 17, 2027 View Other Dates →

Ports:

Departs May 17, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$749

50% Off List

List Price

$1,512

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$741

51% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 24, 2027 View Other Dates →

Ports:

Departs May 24, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$741

51% Off List

List Price

$1,504

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$738

50% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 31, 2027 View Other Dates →

Ports:

Departs May 31, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$738

50% Off List

List Price

$1,465

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$622

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jun 14, 2027 View Other Dates →

Ports:

Departs Jun 14, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$622

54% Off List

List Price

$1,350

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$784

48% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jun 21, 2027 View Other Dates →

Ports:

Departs Jun 21, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$784

48% Off List

List Price

$1,514

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$824

47% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jun 28, 2027 View Other Dates →

Ports:

Departs Jun 28, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$824

47% Off List

List Price

$1,554

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$901

48% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jul 05, 2027 View Other Dates →

Ports:

Departs Jul 05, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$901

48% Off List

List Price

$1,722

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$839

53% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jul 12, 2027 View Other Dates →

Ports:

Departs Jul 12, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$839

53% Off List

List Price

$1,794

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$829

51% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jul 26, 2027 View Other Dates →

Ports:

Departs Jul 26, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$829

51% Off List

List Price

$1,685

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$799

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Aug 02, 2027 View Other Dates →

Ports:

Departs Aug 02, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$799

54% Off List

List Price

$1,724

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$839

51% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Aug 09, 2027 View Other Dates →

Ports:

Departs Aug 09, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$839

51% Off List

List Price

$1,705

View Expanded Details

Showing 1-25 of 1,179 results

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