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MSC Cruises to Caribbean

Onboard an MSC Cruises Caribbean vacation, guests will enjoy all that the Caribbean has to offer with a cruise line that is focused on providing family fun with a distinctly Italian elegance. MSC Cruise Line features the MSC Poesia in the Caribbean, with cruise vacation itineraries that include over 23 destinations and countless unforgettable shore excursions. On all MSC Cruises to the Caribbean, kids sail free, ensuring that each of MSC Cruises’ Caribbean cruises are a great value and a perfect choice for family getaways.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$906

44% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Aug 16, 2027 View Other Dates →

Ports:

Departs Aug 16, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$906

44% Off List

List Price

$1,632

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$892

44% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Aug 23, 2027 View Other Dates →

Ports:

Departs Aug 23, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$892

44% Off List

List Price

$1,590

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$679

48% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Aug 30, 2027 View Other Dates →

Ports:

Departs Aug 30, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$679

48% Off List

List Price

$1,317

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$699

44% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Sep 06, 2027 View Other Dates →

Ports:

Departs Sep 06, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$699

44% Off List

List Price

$1,242

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$665

46% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Sep 13, 2027 View Other Dates →

Ports:

Departs Sep 13, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$665

46% Off List

List Price

$1,242

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$664

47% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Sep 20, 2027 View Other Dates →

Ports:

Departs Sep 20, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$664

47% Off List

List Price

$1,242

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

7-night caribbean cruise

Inside From

$513

51% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Sep 25, 2027 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Puerto Plata → Port Canaveral

Departs Sep 25, 2027 from Port Canaveral, Florida

Up to 3 deals

Inside From

$513

51% Off List

List Price

$1,046

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$699

46% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 11, 2027 View Other Dates →

Ports:

Departs Oct 11, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$699

46% Off List

List Price

$1,301

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$584

53% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Oct 25, 2027 View Other Dates →

Ports:

Departs Oct 25, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$584

53% Off List

List Price

$1,233

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$709

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Nov 01, 2027 View Other Dates →

Ports:

Departs Nov 01, 2027 from La Romana, Dominican Republic

Up to 3 deals

Inside From

$709

49% Off List

List Price

$1,380

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$719

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Nov 08, 2027 View Other Dates →

Ports:

Departs Nov 08, 2027 from La Romana, Dominican Republic

Up to 3 deals

Inside From

$719

49% Off List

List Price

$1,400

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Balcony From

$375

45% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Nov 13, 2026 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Nov 13, 2026 from Miami, Florida

Up to 2 deals

Balcony From

$375

45% Off List

List Price

$679

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

8-night caribbean cruise

Oceanview From

$709

71% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Nov 21, 2026 View Other Dates →

Ports:

Departs Nov 21, 2026 from Miami, Florida

Up to 4 deals

Oceanview From

$709

71% Off List

List Price

$2,426

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

7-night caribbean cruise

Balcony From

$796

58% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Nov 21, 2026 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Puerto Plata → Port Canaveral

Departs Nov 21, 2026 from Port Canaveral, Florida

Up to 2 deals

Balcony From

$796

58% Off List

List Price

$1,900

View Expanded Details

MSC Cruises MSC Poesia itinerary map

11-night caribbean cruise

Oceanview From

$565

83% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Nov 22, 2026 View Other Dates →

Ports:

Miami → Ocho Rios → Cartagena → Colon → Puerto Limon → Roatan → Belize City → Miami

Departs Nov 22, 2026 from Miami, Florida

Up to 3 deals

Oceanview From

$565

83% Off List

List Price

$3,411

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Suite From

$3,619

47% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Nov 23, 2026 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami → Nassau → Miami

Departs Nov 23, 2026 from Miami, Florida

Up to 3 deals

Suite From

$3,619

47% Off List

List Price

$6,776

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Balcony From

$365

52% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Nov 27, 2026 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Nov 27, 2026 from Miami, Florida

Up to 3 deals

Balcony From

$365

52% Off List

List Price

$753

View Expanded Details

MSC Cruises MSC World America itinerary map

7-night caribbean cruise

Inside From

$496

65% Off List

MSC Cruises – MSC World America

Date:

Nov 28, 2026 View Other Dates →

Ports:

Miami → Puerto Plata → San Juan → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Nov 28, 2026 from Miami, Florida

Up to 2 deals

Inside From

$496

65% Off List

List Price

$1,407

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$689

52% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Nov 30, 2026 View Other Dates →

Ports:

Departs Nov 30, 2026 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$689

52% Off List

List Price

$1,426

View Expanded Details

MSC Cruises MSC Poesia itinerary map

10-night caribbean cruise

Oceanview From

$536

75% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Dec 03, 2026

Ports:

Miami → Curacao → Oranjestad → Cabo Rojo → Ocho Rios → George Town Cayman Islands → Miami

Departs Dec 03, 2026 from Miami, Florida

Up to 2 deals

Oceanview From

$536

75% Off List

List Price

$2,116

View Expanded Details

MSC Cruises MSC Poesia itinerary map

20-night caribbean cruise

Inside From

$1,336

64% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Dec 03, 2026

Ports:

Departs Dec 03, 2026 from Miami, Florida

Up to 2 deals

Inside From

$1,336

64% Off List

List Price

$3,732

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,568

50% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Dec 04, 2026 View Other Dates →

Ports:

Departs Dec 04, 2026 from Fort de France, Martinique

Up to 3 deals

Inside From

$1,568

50% Off List

List Price

$3,161

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

7-night caribbean cruise

Inside From

$304

66% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Dec 05, 2026 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Puerto Plata → Port Canaveral

Departs Dec 05, 2026 from Port Canaveral, Florida

Up to 3 deals

Inside From

$304

66% Off List

List Price

$900

View Expanded Details

MSC Cruises MSC World Europa itinerary map

7-night caribbean cruise

Inside From

$989

MSC Cruises – MSC World Europa

2.03 Reviews

Date:

Dec 05, 2026

Ports:

Departs Dec 05, 2026 from Fort de France, Martinique

Up to 2 deals

Inside From

$989

View Expanded Details

MSC Cruises MSC Seascape itinerary map

7-night caribbean cruise

Balcony From

$530

66% Off List

MSC Cruises – MSC Seascape

4.120 Reviews

Date:

Dec 06, 2026 View Other Dates →

Ports:

Galveston → Costa Maya → Roatan → Cozumel → Galveston

Departs Dec 06, 2026 from Galveston, Texas

Up to 2 deals

Balcony From

$530

66% Off List

List Price

$1,575

View Expanded Details

Showing 26-50 of 1,178 results

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