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MSC Cruises to Caribbean

Onboard an MSC Cruises Caribbean vacation, guests will enjoy all that the Caribbean has to offer with a cruise line that is focused on providing family fun with a distinctly Italian elegance. MSC Cruise Line features the MSC Poesia in the Caribbean, with cruise vacation itineraries that include over 23 destinations and countless unforgettable shore excursions. On all MSC Cruises to the Caribbean, kids sail free, ensuring that each of MSC Cruises’ Caribbean cruises are a great value and a perfect choice for family getaways.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Seaside itinerary map

4-night caribbean cruise

Inside From

$260

51% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Jan 04, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami

Departs Jan 04, 2027 from Miami, Florida

Up to 2 deals

Inside From

$260

51% Off List

List Price

$527

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$679

52% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jan 04, 2027 View Other Dates →

Ports:

Departs Jan 04, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$679

52% Off List

List Price

$1,401

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Balcony From

$694

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Jan 04, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami → Nassau → Miami

Departs Jan 04, 2027 from Miami, Florida

Up to 1 deal

Balcony From

$694

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$679

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jan 11, 2027

Ports:

Departs Jan 11, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$679

54% Off List

List Price

$1,472

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

14-night caribbean cruise

Inside From

$751

63% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Jan 16, 2027 View Other Dates →

Ports:

Departs Jan 16, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$751

63% Off List

List Price

$2,036

View Expanded Details

MSC Cruises MSC World America itinerary map

14-night caribbean cruise

Balcony From

$2,114

47% Off List

MSC Cruises – MSC World America

Date:

Jan 23, 2027 View Other Dates →

Ports:

Departs Jan 23, 2027 from Miami, Florida

Up to 2 deals

Balcony From

$2,114

47% Off List

List Price

$3,986

View Expanded Details

MSC Cruises MSC Poesia itinerary map

11-night caribbean cruise

Inside From

$1,028

53% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Jan 24, 2027 View Other Dates →

Ports:

Miami → Montego Bay → Cartagena → Colon → Puerto Limon → Roatan → Belize City → Miami

Departs Jan 24, 2027 from Miami, Florida

Up to 3 deals

Inside From

$1,028

53% Off List

List Price

$2,189

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Balcony From

$638

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Jan 25, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami → Nassau → Miami

Departs Jan 25, 2027 from Miami, Florida

Up to 1 deal

Balcony From

$638

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,668

51% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Jan 29, 2027 View Other Dates →

Ports:

Departs Jan 29, 2027 from Fort de France, Martinique

Up to 3 deals

Inside From

$1,668

51% Off List

List Price

$3,401

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

14-night caribbean cruise

Inside From

$790

63% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Jan 30, 2027 View Other Dates →

Ports:

Departs Jan 30, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$790

63% Off List

List Price

$2,112

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Inside From

$374

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Feb 01, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami → Nassau → Miami

Departs Feb 01, 2027 from Miami, Florida

Up to 1 deal

Inside From

$374

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$619

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Feb 01, 2027 View Other Dates →

Ports:

Departs Feb 01, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$619

54% Off List

List Price

$1,349

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

6-night caribbean cruise

Inside From

$413

77% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 07, 2027 View Other Dates →

Ports:

Miami → Grand Turk → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs Feb 07, 2027 from Miami, Florida

Up to 3 deals

Inside From

$413

77% Off List

List Price

$1,834

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

14-night caribbean cruise

Inside From

$1,276

46% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 07, 2027 View Other Dates →

Ports:

Departs Feb 07, 2027 from Miami, Florida

Up to 3 deals

Inside From

$1,276

46% Off List

List Price

$2,357

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$679

54% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Feb 08, 2027 View Other Dates →

Ports:

Departs Feb 08, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$679

54% Off List

List Price

$1,475

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,848

48% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Feb 11, 2027

Ports:

Departs Feb 11, 2027 from Bridgetown, Barbados

Up to 3 deals

Inside From

$1,848

48% Off List

List Price

$3,564

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

8-night caribbean cruise

Inside From

$790

41% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 13, 2027 View Other Dates →

Ports:

Departs Feb 13, 2027 from Miami, Florida

Up to 4 deals

Inside From

$790

41% Off List

List Price

$1,346

View Expanded Details

MSC Cruises MSC Meraviglia itinerary map

14-night caribbean cruise

Inside From

$1,236

46% Off List

MSC Cruises – MSC Meraviglia

3.889 Reviews

Date:

Feb 13, 2027

Ports:

Departs Feb 13, 2027 from Miami, Florida

Up to 3 deals

Inside From

$1,236

46% Off List

List Price

$2,277

View Expanded Details

MSC Cruises MSC Poesia itinerary map

11-night caribbean cruise

Inside From

$1,268

41% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Feb 14, 2027 View Other Dates →

Ports:

Miami → Ocho Rios → Cartagena → Colon → Puerto Limon → Roatan → Belize City → Miami

Departs Feb 14, 2027 from Miami, Florida

Up to 3 deals

Inside From

$1,268

41% Off List

List Price

$2,159

View Expanded Details

MSC Cruises MSC Poesia itinerary map

21-night caribbean cruise

Inside From

$2,705

35% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Feb 14, 2027 View Other Dates →

Ports:

Departs Feb 14, 2027 from Miami, Florida

Up to 2 deals

Inside From

$2,705

35% Off List

List Price

$4,156

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Inside From

$540

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Feb 15, 2027 View Other Dates →

Ports:

Miami → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Miami → Nassau → Miami

Departs Feb 15, 2027 from Miami, Florida

Up to 1 deal

Inside From

$540

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

14-night caribbean cruise

Inside From

$740

67% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Feb 20, 2027 View Other Dates →

Ports:

Departs Feb 20, 2027 from Port Canaveral, Florida

Up to 2 deals

Inside From

$740

67% Off List

List Price

$2,236

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$729

51% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Feb 22, 2027 View Other Dates →

Ports:

Departs Feb 22, 2027 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$729

51% Off List

List Price

$1,496

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,818

48% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Feb 25, 2027 View Other Dates →

Ports:

Departs Feb 25, 2027 from Bridgetown, Barbados

Up to 3 deals

Inside From

$1,818

48% Off List

List Price

$3,504

View Expanded Details

MSC Cruises MSC Poesia itinerary map

21-night caribbean cruise

Inside From

$2,805

32% Off List

MSC Cruises – MSC Poesia

3.929 Reviews

Date:

Feb 25, 2027 View Other Dates →

Ports:

Departs Feb 25, 2027 from Miami, Florida

Up to 2 deals

Inside From

$2,805

32% Off List

List Price

$4,096

View Expanded Details

Showing 76-100 of 1,178 results

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