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Best South America Cruises

Showing 51-75 of 531 results
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7-night south america cruise
$4,648
AmaWaterways – AmaMelodia
Departs Nov 11, 2026 from Barranquilla, Colombia
Up to 4 deals including Avoya Exclusives
16-night south america cruise
$2,309
Holland America – Oosterdam
4.2 (212)
Departs Nov 18, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
7-night south america cruise
$4,598
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Nov 21, 2026 from Cartagena, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,698
AmaWaterways – AmaMelodia
Departs Nov 25, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
27-night south america cruise
$5,034
Holland America – Volendam
4.3 (73)
Departs Nov 25, 2026 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
7-night south america cruise
$5,348
AmaWaterways – AmaMelodia
Departs Dec 09, 2026 from Barranquilla, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,598
AmaWaterways – AmaMelodia
Departs Dec 16, 2026 from Cartagena, Colombia
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$4,148
AmaWaterways – AmaMelodia
Departs Dec 30, 2026 from Cartagena, Colombia
Up to 1 deal
7-night south america cruise
$4,149
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jan 02, 2027 from Cartagena, Spain
Up to 1 deal
11-night south america cruise
$12,549
59% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 22, 2027 from Rio de Janeiro, Brazil
Up to 2 deals including an Avoya Exclusive
22-night south america cruise
$8,019
Holland America – Oosterdam
4.2 (212)
Departs Feb 01, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
Avoya Exclusive Rate
21-night south america cruise
$6,649
50% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Feb 14, 2027 from Santiago (Valparaiso), Chile
Up to 4 deals including an Avoya Exclusive
Secret Rate
7-night south america cruise
$6,398
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Feb 27, 2027 from Cartagena, Colombia
Up to 2 deals
18-night south america cruise
$12,530
Silversea – Silver Nova
5.0 (5)
Departs Mar 05, 2027 from Santiago (Valparaiso), Chile
Up to 2 deals including an Avoya Exclusive
15-night south america cruise
$2,674
Holland America – Oosterdam
4.2 (212)
Departs Mar 09, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
22-night south america cruise
$20,949
56% Off List
Regent Cruises – Seven Seas Grandeur
5.0 (3)
Departs Mar 09, 2027 from Panama City (Fuerte Amador), Panama
Up to 2 deals including an Avoya Exclusive
16-night south america cruise
$12,499
60% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Mar 10, 2027 from Lima (Callao), Peru
Up to 2 deals including an Avoya Exclusive
7-night south america cruise
$5,748
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 13, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 20, 2027 from Barranquilla, Colombia
Up to 1 deal
16-night south america cruise
$2,459
Holland America – Oosterdam
4.2 (212)
Departs Mar 24, 2027 from San Antonio, Chile
Up to 3 deals including Avoya Exclusives
7-night south america cruise
$5,198
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 27, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,348
AmaWaterways – AmaMelodia
Departs Mar 31, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,299
AmaWaterways – AmaMelodia
Departs Apr 07, 2027 from Cartagena, Colombia
Up to 2 deals
7-night south america cruise
$4,698
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 10, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,899
AmaWaterways – AmaMelodia
Departs Apr 14, 2027 from Barranquilla, Colombia
Up to 2 deals

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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