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Best South America Cruises

Showing 101-125 of 473 results
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7-night south america cruise
$3,799
AmaWaterways – AmaMelodia
Departs Jun 02, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$3,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 05, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,448
AmaWaterways – AmaMelodia
Departs Jun 09, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,649
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 12, 2027 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$3,649
AmaWaterways – AmaMelodia
Departs Jun 16, 2027 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$4,448
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Jun 26, 2027 from Barranquilla, Colombia
Up to 1 deal
14-night south america cruise
$1,330
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 28, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
22-night south america cruise
$14,099
61% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Nov 09, 2026 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
18-night south america cruise
$1,819
Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Secret Rate
33-night south america cruise
$4,511
Princess Cruises – Majestic Princess
4.3 (66)
Departs Nov 19, 2026 from Fort Lauderdale, Florida
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$2,778
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 05, 2026 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
15-night south america cruise
$3,321
Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$2,074
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
15-night south america cruise
$3,275
62% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Dec 19, 2026 from Miami, Florida
Up to 6 deals including an Avoya Exclusive
Secret Rate
15-night south america cruise
$2,001
Princess Cruises – Majestic Princess
4.3 (66)
Departs Dec 22, 2026 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$6,937
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 02, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
21-night south america cruise
$5,760
55% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Jan 03, 2027 from Lima (Callao), Peru
Up to 6 deals including Avoya Exclusives
18-night south america cruise
$9,675
70% Off List
Regent Cruises – Seven Seas Mariner
4.5 (103)
Departs Jan 04, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
17-night south america cruise
$3,196
Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 06, 2027 from Buenos Aires, Argentina
Up to 7 deals including an Avoya Exclusive
Secret Rate
17-night south america cruise
$3,286
Princess Cruises – Majestic Princess
4.3 (66)
Departs Jan 23, 2027 from Buenos Aires, Argentina
Up to 7 deals including an Avoya Exclusive
Secret Rate
21-night south america cruise
$6,140
52% Off List
Oceania Cruises – Insignia
4.3 (171)
Departs Jan 24, 2027 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
Secret Rate
14-night south america cruise
$12,077
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 30, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
22-night south america cruise
$4,534
Holland America – Oosterdam
4.2 (212)
Departs Feb 01, 2027 from Buenos Aires, Argentina
Up to 4 deals including Avoya Exclusives
Avoya Exclusive Rate
14-night south america cruise
$10,092
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 13, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
18-night south america cruise
$11,765
Silversea – Silver Nova
5.0 (5)
Departs Mar 05, 2027 from Santiago (Valparaiso), Chile
Up to 2 deals including an Avoya Exclusive

South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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