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Best South America Cruises

Showing 1-25 of 545 results
21-night south america cruise
$7,200
55% Off List
Oceania Cruises – Marina
4.5 (399)
Departs Mar 17, 2026 from Rio de Janeiro, Brazil
Up to 5 deals including an Avoya Exclusive
14-night south america cruise
$2,537
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Dec 05, 2026 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
14-night south america cruise
$3,565
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Jan 16, 2027 from Buenos Aires, Argentina
Up to 6 deals including Avoya Exclusives
Avoya Exclusive Rate
23-night south america cruise
$6,939
Azamara Cruises – Azamara Journey
4.6 (158)
Departs Jan 25, 2027 from Bridgetown, Barbados
Up to 2 deals including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
21-night south america cruise
$8,629
Azamara Cruises – Azamara Journey
4.6 (158)
Departs Feb 17, 2027 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
19-night south america cruise
$5,559
Azamara Cruises – Azamara Journey
4.6 (158)
Departs Mar 10, 2027 from San Antonio, Chile
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
17-night south america cruise
$5,349
Azamara Cruises – Azamara Quest
4.6 (126)
Departs May 24, 2027 from San Diego, California
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
9-night south america cruise
$3,109
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Jan 05, 2028 from Miami, Florida
Avoya Exclusive Rate
10-night south america cruise
$2,939
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Jan 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 1 deal including an Avoya Exclusive
Avoya Exclusive Rate
10-night south america cruise
$2,949
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Jan 24, 2028 from Santiago (Valparaiso), Chile
Up to 1 deal including an Avoya Exclusive
Avoya Exclusive Rate
13-night south america cruise
$3,719
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Feb 03, 2028 from Ushuaia, Argentina
Up to 1 deal including an Avoya Exclusive
Avoya Exclusive Rate
12-night south america cruise
$3,849
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Feb 16, 2028 from Buenos Aires, Argentina
Avoya Exclusive Rate
14-night south america cruise
$4,249
Azamara Cruises – Azamara Quest
4.6 (126)
Departs Feb 28, 2028 from Rio de Janeiro, Brazil
Up to 1 deal including an Avoya Exclusive
Avoya Exclusive Rate
14-night south america cruise
$8,441
Celebrity Cruises – Celebrity Equinox
4.6 (604)
Departs Feb 28, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
7-night south america cruise
$4,848
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 07, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,948
AmaWaterways – AmaMelodia
Departs Mar 11, 2026 from Cartagena, Spain
7-night south america cruise
$5,449
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 21, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,648
AmaWaterways – AmaMelodia
Departs Mar 25, 2026 from Cartagena, Spain
7-night south america cruise
$8,348
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Mar 28, 2026 from Cartagena, Spain
7-night south america cruise
$6,248
AmaWaterways – AmaMelodia
Departs Apr 01, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,148
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 04, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$5,648
AmaWaterways – AmaMelodia
Departs Apr 08, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,648
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 11, 2026 from Cartagena, Spain
Up to 1 deal
7-night south america cruise
$5,548
AmaWaterways – AmaMelodia
Departs Apr 15, 2026 from Barranquilla, Colombia
Up to 1 deal
7-night south america cruise
$4,549
AmaWaterways – AmaMagdalena
5.0 (1)
Departs Apr 18, 2026 from Barranquilla, Colombia
Up to 1 deal
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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