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Best South America Cruises

Showing 1-25 of 826 results
21-night south america cruise
Inside From
$7,899
Oceania Cruises – Insignia
4.3172 Reviews
Departs Jan 03, 2027 from Lima (Callao), Peru
Up to 5 deals including Avoya Exclusives
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15-night south america cruise
Inside From
$2,402
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Dec 07, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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21-night south america cruise
Inside From
$7,949
50% Off List
Oceania Cruises – Insignia
4.3172 Reviews
Departs Feb 14, 2027 from Santiago (Valparaiso), Chile
Up to 4 deals including an Avoya Exclusive
Secret Rate
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21-night south america cruise
Oceanview From
$9,779
20% Off
Azamara Cruises – Azamara Journey
4.6159 Reviews
Departs Feb 17, 2027 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
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21-night south america cruise
Inside From
$6,699
50% Off List
Oceania Cruises – Insignia
4.3172 Reviews
Departs Mar 19, 2027 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
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17-night south america cruise
Inside From
$4,029
19% Off
Azamara Cruises – Azamara Quest
4.6127 Reviews
Departs May 24, 2027 from San Diego, California
Up to 1 deal including an Avoya Exclusive
Secret Rate
Avoya Exclusive Rate
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9-night south america cruise
Inside From
$2,969
19% Off
Azamara Cruises – Azamara Quest
4.6127 Reviews
Departs Jan 05, 2028 from Miami, Florida
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
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17-night south america cruise
Inside From
$3,400
5% Off
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Jan 07, 2028 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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10-night south america cruise
Oceanview From
$3,829
20% Off
Azamara Cruises – Azamara Quest
4.6127 Reviews
Departs Jan 14, 2028 from Panama City (Fuerte Amador), Panama
Up to 3 deals including Avoya Exclusives
Avoya Exclusive Rate
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25-night south america cruise
Oceanview From
$18,099
50% Off List
Oceania Cruises – Insignia
4.3172 Reviews
Departs Nov 24, 2026 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
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14-night south america cruise
Inside From
$2,157
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Dec 05, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
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14-night south america cruise
Inside From
$2,261
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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15-night south america cruise
Inside From
$4,399
Oceania Cruises – Insignia
4.3172 Reviews
Departs Dec 19, 2026 from Miami, Florida
Up to 4 deals including an Avoya Exclusive
Secret Rate
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14-night south america cruise
Oceanview From
$3,517
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Jan 02, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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18-night south america cruise
Suite From
$18,899
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Jan 04, 2027 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
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14-night south america cruise
Balcony From
$4,065
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Jan 16, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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14-night south america cruise
Balcony From
$5,292
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Jan 30, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
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18-night south america cruise
Suite From
$10,960
69% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Feb 02, 2027 from Buenos Aires, Argentina
Up to 4 deals including Avoya Exclusives
Secret Rate
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14-night south america cruise
Inside From
$3,214
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Feb 13, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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18-night south america cruise
Suite From
$11,600
68% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Feb 20, 2027 from Buenos Aires, Argentina
Up to 3 deals including Avoya Exclusives
Secret Rate
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14-night south america cruise
Oceanview From
$3,202
Celebrity Cruises – Celebrity Equinox
4.6604 Reviews
Departs Feb 27, 2027 from Buenos Aires, Argentina
Up to 5 deals including Avoya Exclusives
Avoya Exclusive Rate
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19-night south america cruise + tour
Inside From
$4,848
Norwegian Cruise Line – Norwegian Star
4.1162 Reviews
Departs Dec 15, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
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16-night south america cruise
Inside From
$4,059
Norwegian Cruise Line – Norwegian Star
4.1162 Reviews
Departs Dec 17, 2027 from Buenos Aires, Argentina
Up to 6 deals including an Avoya Exclusive
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19-night south america cruise + tour
Inside From
$3,928
Norwegian Cruise Line – Norwegian Star
4.1162 Reviews
Departs Dec 30, 2027 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
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14-night south america cruise
Inside From
$4,249
13% Off
Azamara Cruises – Azamara Quest
4.6127 Reviews
Departs Feb 28, 2028 from Rio de Janeiro, Brazil
Up to 2 deals including an Avoya Exclusive
Avoya Exclusive Rate
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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