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Best South America Cruises

Showing 226-250 of 826 results
4-night south america cruise
Inside From
$525
50% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 13, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Balcony From
$1,186
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 15, 2026 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,056
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 16, 2026 from Maceio
Up to 3 deals
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3-night south america cruise
Balcony From
$638
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 17, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,399
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 19, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$3,485
Windstar Cruises – Wind Star
4.689 Reviews
Departs Dec 19, 2026 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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2-night south america cruise
Inside From
$239
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
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7-night south america cruise
Balcony From
$1,219
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
View Expanded Details
8-night south america cruise
Oceanview From
$2,942
Windstar Cruises – Star Legend
4.586 Reviews
Departs Dec 20, 2026 from Balboa, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$1,036
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 22, 2026 from Rio de Janeiro, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,869
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 26, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$3,940
Windstar Cruises – Wind Star
4.689 Reviews
Departs Dec 26, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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8-night south america cruise
Oceanview From
$3,238
Windstar Cruises – Star Legend
4.586 Reviews
Departs Dec 28, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$1,413
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 29, 2026 from Rio de Janeiro, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,846
50% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 29, 2026 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,006
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 02, 2027 from Paranagua, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,319
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 02, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$3,345
Windstar Cruises – Wind Star
4.689 Reviews
Departs Jan 02, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$1,019
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 03, 2027 from Itajai
Up to 2 deals
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7-night south america cruise
Inside From
$1,006
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 05, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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7-night south america cruise
Oceanview From
$2,878
Windstar Cruises – Star Legend
4.586 Reviews
Departs Jan 05, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$1,256
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 06, 2027 from Maceio
Up to 3 deals
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13-night south america cruise + tour
Suite From
$21,997
Seabourn – Seabourn Venture
5.02 Reviews
Departs Jan 07, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Inside From
$1,006
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 09, 2027 from Paranagua, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,019
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 10, 2027 from Itajai
Up to 2 deals
View Expanded Details
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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