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Best South America Cruises

Showing 251-275 of 826 results
13-night south america cruise + tour
Suite From
$21,997
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Jan 10, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Inside From
$1,026
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 12, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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7-night south america cruise
Oceanview From
$1,306
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 12, 2027 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$2,878
Windstar Cruises – Star Legend
4.586 Reviews
Departs Jan 12, 2027 from Puerto Caldera (Puntarenas), Costa Rica
Up to 3 deals including Avoya Exclusives
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7-night south america cruise
Inside From
$1,316
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 13, 2027 from Maceio
Up to 3 deals
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9-night south america cruise
Inside From
$2,242
34% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Jan 14, 2027 from Buenos Aires, Argentina
Up to 3 deals
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7-night south america cruise
Inside From
$1,076
46% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 17, 2027 from Itajai
Up to 3 deals
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7-night south america cruise
Oceanview From
$1,166
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 19, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$2,878
Windstar Cruises – Star Legend
4.586 Reviews
Departs Jan 19, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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11-night south america cruise + tour
Suite From
$13,798
Seabourn – Seabourn Venture
5.02 Reviews
Departs Jan 19, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Inside From
$1,246
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 20, 2027 from Maceio
Up to 3 deals
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7-night south america cruise
Inside From
$976
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 23, 2027 from Paranagua, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,269
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 23, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$956
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 24, 2027 from Itajai
Up to 3 deals
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7-night south america cruise
Oceanview From
$5,900
Windstar Cruises – Wind Star
4.689 Reviews
Departs Jan 24, 2027 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$1,106
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 26, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,256
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 26, 2027 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$2,878
Windstar Cruises – Star Legend
4.586 Reviews
Departs Jan 26, 2027 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
View Expanded Details
7-night south america cruise
Inside From
$1,316
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 27, 2027 from Maceio
Up to 3 deals
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13-night south america cruise + tour
Suite From
$15,793
Seabourn – Seabourn Venture
5.02 Reviews
Departs Jan 29, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Inside From
$976
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 30, 2027 from Paranagua, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,319
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 30, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Balcony From
$1,286
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 31, 2027 from Itajai
Up to 3 deals
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8-night south america cruise
Inside From
$3,970
Windstar Cruises – Wind Star
4.689 Reviews
Departs Jan 31, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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29-night south america cruise
Oceanview From
$8,961
Windstar Cruises – Wind Star
4.689 Reviews
Departs Jan 31, 2027 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
View Expanded Details
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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