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Best South America Cruises

Showing 301-325 of 826 results
7-night south america cruise
Inside From
$1,119
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Feb 27, 2027 from Santos, Brazil
Up to 3 deals
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8-night south america cruise
Inside From
$1,985
34% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Feb 27, 2027 from Buenos Aires, Argentina
Up to 3 deals
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7-night south america cruise
Oceanview From
$949
MSC Cruises – MSC Musica
3.54 Reviews
Departs Feb 28, 2027 from Itajai
Up to 2 deals
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7-night south america cruise
Inside From
$781
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 02, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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21-night south america cruise + tour
Suite From
$18,328
Seabourn – Seabourn Venture
5.02 Reviews
Departs Mar 02, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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35-night south america cruise + tour
Suite From
$26,773
Seabourn – Seabourn Venture
5.02 Reviews
Departs Mar 02, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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56-night south america cruise + tour
Suite From
$34,123
Seabourn – Seabourn Venture
5.02 Reviews
Departs Mar 02, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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11-night south america cruise + tour
Suite From
$11,243
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 03, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Inside From
$761
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 06, 2027 from Paranagua, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,079
47% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Mar 06, 2027 from Santos, Brazil
Up to 3 deals
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8-night south america cruise
Balcony From
$1,289
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 07, 2027 from Itajai
Up to 2 deals
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4-night south america cruise
Balcony From
$559
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 09, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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5-night south america cruise
Balcony From
$799
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 09, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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6-night south america cruise
Balcony From
$899
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 09, 2027 from Rio de Janeiro, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,066
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Mar 09, 2027 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,106
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Mar 10, 2027 from Maceio
Up to 3 deals
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1-night south america cruise
Balcony From
$299
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 13, 2027 from Paranagua, Brazil
Up to 2 deals
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2-night south america cruise
Balcony From
$409
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 13, 2027 from Paranagua, Brazil
Up to 2 deals
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11-night south america cruise + tour
Suite From
$15,297
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 13, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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25-night south america cruise + tour
Suite From
$28,097
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 13, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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44-night south america cruise + tour
Suite From
$43,697
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 13, 2027 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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1-night south america cruise
Inside From
$199
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 14, 2027 from Itajai
Up to 2 deals
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4-night south america cruise
Inside From
$536
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 15, 2027 from Santos, Brazil
Up to 3 deals
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3-night south america cruise
Inside From
$478
48% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Mar 19, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,119
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Mar 20, 2027 from Santos, Brazil
Up to 3 deals
View Expanded Details
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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