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Best South America Cruises

Showing 351-375 of 827 results
7-night south america cruise
Oceanview From
$2,878
Windstar Cruises – Star Pride
4.595 Reviews
Departs Jan 03, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$3,543
Windstar Cruises – Star Pride
4.595 Reviews
Departs Jan 10, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$3,298
Windstar Cruises – Star Pride
4.595 Reviews
Departs Jan 17, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Inside From
$2,878
Windstar Cruises – Star Pride
4.595 Reviews
Departs Jan 24, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$3,123
Windstar Cruises – Star Pride
4.595 Reviews
Departs Jan 31, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$3,123
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 07, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$3,403
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 14, 2028 from Colon, Panama
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$3,247
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 21, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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14-night south america cruise
Oceanview From
$6,378
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 21, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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21-night south america cruise
Oceanview From
$8,887
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 21, 2028 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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21-night south america cruise + tour
Suite From
$27,497
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Feb 24, 2028 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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7-night south america cruise
Oceanview From
$4,111
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 28, 2028 from Balboa, Panama
Up to 2 deals including an Avoya Exclusive
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14-night south america cruise
Oceanview From
$6,095
Windstar Cruises – Star Pride
4.595 Reviews
Departs Feb 28, 2028 from Balboa, Panama
Up to 2 deals including an Avoya Exclusive
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11-night south america cruise + tour
Suite From
$14,997
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 15, 2028 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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26-night south america cruise + tour
Suite From
$25,997
Seabourn – Seabourn Pursuit
5.01 Reviews
Departs Mar 25, 2028 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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1-night south america cruise
Oceanview From
$153
MSC Cruises – MSC Divina
3.892 Reviews
Departs Nov 15, 2026 from Rio de Janeiro, Brazil
Up to 2 deals
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4-night south america cruise
Balcony From
$719
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Nov 28, 2026 from Salvador, Brazil
Up to 2 deals
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3-night south america cruise
Inside From
$569
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Nov 29, 2026 from Santos, Brazil
Up to 2 deals
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4-night south america cruise
Inside From
$589
49% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Nov 29, 2026 from Santos, Brazil
Up to 3 deals
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1-night south america cruise
Inside From
$90
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 01, 2026 from Rio de Janeiro, Brazil
Up to 2 deals
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3-night south america cruise
Inside From
$448
59% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 02, 2026 from Santos, Brazil
Up to 3 deals
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3-night south america cruise
Inside From
$559
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 02, 2026 from Santos, Brazil
Up to 2 deals
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8-night south america cruise
Inside From
$1,817
34% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 03, 2026 from Buenos Aires, Argentina
Up to 3 deals
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3-night south america cruise
Oceanview From
$641
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 05, 2026 from Santos, Brazil
Up to 2 deals
View Expanded Details
4-night south america cruise
Inside From
$689
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 05, 2026 from Santos, Brazil
Up to 2 deals
View Expanded Details
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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