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Best South America Cruises

Showing 376-400 of 827 results
5-night south america cruise
Balcony From
$956
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 05, 2026 from Santos, Brazil
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8-night south america cruise
Inside From
$1,119
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 05, 2026 from Santos, Brazil
Up to 2 deals
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8-night south america cruise
Inside From
$1,119
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 06, 2026 from Camboriu
Up to 2 deals
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8-night south america cruise
Balcony From
$1,581
50% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 06, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
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7-night south america cruise
Balcony From
$1,276
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 08, 2026 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$996
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 09, 2026 from Maceio
Up to 3 deals
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7-night south america cruise
Balcony From
$1,777
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 10, 2026 from Buenos Aires, Argentina
Up to 2 deals
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8-night south america cruise
Balcony From
$2,287
35% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 11, 2026 from Buenos Aires, Argentina
Up to 3 deals
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7-night south america cruise
Inside From
$1,009
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 12, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,359
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 13, 2026 from Santos, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,379
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 14, 2026 from Camboriu
Up to 2 deals
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3-night south america cruise
Inside From
$479
49% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Dec 15, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,537
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 17, 2026 from Buenos Aires, Argentina
Up to 2 deals
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3-night south america cruise
Inside From
$459
MSC Cruises – MSC Divina
3.892 Reviews
Departs Dec 18, 2026 from Santos, Brazil
Up to 1 deal
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8-night south america cruise
Inside From
$2,075
35% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 19, 2026 from Buenos Aires, Argentina
Up to 3 deals
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7-night south america cruise
Inside From
$1,499
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 20, 2026 from Santos, Brazil
Up to 2 deals
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5-night south america cruise
Inside From
$919
49% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Dec 21, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,479
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 21, 2026 from Camboriu
Up to 2 deals
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7-night south america cruise
Inside From
$1,386
49% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 22, 2026 from Salvador, Brazil
Up to 3 deals
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9-night south america cruise
Balcony From
$2,186
46% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 22, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
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3-night south america cruise
Inside From
$437
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 23, 2026 from Maceio
Up to 2 deals
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7-night south america cruise
Inside From
$1,527
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 24, 2026 from Buenos Aires, Argentina
Up to 2 deals
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3-night south america cruise
Inside From
$559
49% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Dec 26, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,584
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 27, 2026 from Santos, Brazil
Up to 2 deals
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9-night south america cruise
Inside From
$2,735
36% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 27, 2026 from Buenos Aires, Argentina
Up to 3 deals
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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