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Best South America Cruises

Showing 401-425 of 827 results
7-night south america cruise
Inside From
$1,567
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Dec 31, 2026 from Buenos Aires, Argentina
Up to 2 deals
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8-night south america cruise
Balcony From
$2,809
50% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Dec 31, 2026 from Rio de Janeiro, Brazil
Up to 3 deals
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3-night south america cruise
Oceanview From
$669
49% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Jan 02, 2027 from Santos, Brazil
Up to 3 deals
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4-night south america cruise
Balcony From
$941
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 02, 2027 from Santos, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,499
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 04, 2027 from Camboriu
Up to 2 deals
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7-night south america cruise
Inside From
$1,316
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 05, 2027 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,477
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 07, 2027 from Buenos Aires, Argentina
Up to 2 deals
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9-night south america cruise
Balcony From
$2,167
56% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Jan 08, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,269
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 09, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,519
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 10, 2027 from Santos, Brazil
Up to 2 deals
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7-night south america cruise
Inside From
$1,519
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 11, 2027 from Camboriu
Up to 2 deals
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7-night south america cruise
Inside From
$1,089
MSC Cruises – MSC Musica
3.54 Reviews
Departs Jan 16, 2027 from Paranagua, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,319
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 16, 2027 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,449
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 17, 2027 from Santos, Brazil
Up to 2 deals
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9-night south america cruise
Balcony From
$1,776
56% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Jan 17, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,429
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 18, 2027 from Camboriu
Up to 2 deals
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7-night south america cruise
Inside From
$1,316
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Jan 19, 2027 from Salvador, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,417
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 21, 2027 from Buenos Aires, Argentina
Up to 2 deals
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17-night south america cruise
Inside From
$1,750
Cunard – Queen Anne
5.01 Reviews
Departs Jan 22, 2027 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
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37-night south america cruise
Inside From
$5,550
Cunard – Queen Anne
5.01 Reviews
Departs Jan 22, 2027 from Fort Lauderdale, Florida
Up to 2 deals including an Avoya Exclusive
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56-night south america cruise
Inside From
$6,100
Cunard – Queen Anne
5.01 Reviews
Departs Jan 22, 2027 from Fort Lauderdale, Florida
Up to 3 deals including Avoya Exclusives
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3-night south america cruise
Inside From
$669
72% Off List
MSC Cruises – MSC Divina
3.892 Reviews
Departs Jan 23, 2027 from Santos, Brazil
Up to 2 deals
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9-night south america cruise
Inside From
$2,220
34% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Jan 23, 2027 from Buenos Aires, Argentina
Up to 3 deals
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7-night south america cruise
Inside From
$1,379
MSC Cruises – MSC Seaview
4.65 Reviews
Departs Jan 24, 2027 from Santos, Brazil
Up to 2 deals
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9-night south america cruise
Balcony From
$1,870
56% Off List
MSC Cruises – MSC Splendida
4.79 Reviews
Departs Jan 26, 2027 from Rio de Janeiro, Brazil
Up to 3 deals
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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