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Best South America Cruises

Showing 126-150 of 826 results
15-night south america cruise
Inside From
$2,675
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Dec 06, 2028 from San Antonio, Chile
Up to 4 deals including an Avoya Exclusive
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20-night south america cruise + tour
Inside From
$6,625
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Dec 06, 2028 from San Antonio, Chile
Up to 3 deals including an Avoya Exclusive
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22-night south america cruise + tour
Inside From
$7,075
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Dec 16, 2028 from Rio de Janeiro, Brazil
Up to 4 deals including an Avoya Exclusive
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17-night south america cruise
Inside From
$3,125
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Dec 21, 2028 from Buenos Aires, Argentina
Up to 4 deals including an Avoya Exclusive
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22-night south america cruise + tour
Inside From
$7,425
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Jan 02, 2029 from Rio de Janeiro, Brazil
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64-night south america cruise
Oceanview From
$20,544
Princess Cruises – Coral Princess
4.4127 Reviews
Departs Jan 04, 2029 from Fort Lauderdale, Florida
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17-night south america cruise
Inside From
$3,475
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Jan 07, 2029 from Buenos Aires, Argentina
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25-night south america cruise
Suite From
$19,899
59% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Jan 07, 2029 from Miami, Florida
Up to 3 deals including an Avoya Exclusive
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22-night south america cruise + tour
Inside From
$7,675
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Jan 19, 2029 from Rio de Janeiro, Brazil
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17-night south america cruise
Inside From
$3,725
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Jan 24, 2029 from Buenos Aires, Argentina
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17-night south america cruise
Suite From
$14,999
59% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
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25-night south america cruise
Suite From
$20,999
61% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Feb 01, 2029 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
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8-night south america cruise
Suite From
$7,099
63% Off List
Regent Cruises – Seven Seas Mariner
4.5103 Reviews
Departs Feb 18, 2029 from Santiago (Valparaiso), Chile
Up to 3 deals including an Avoya Exclusive
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7-night south america cruise
Balcony From
$5,148
AmaWaterways – AmaMelodia
Departs Nov 18, 2026 from Cartagena, Colombia
Up to 2 deals
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7-night south america cruise
Suite From
$7,248
AmaWaterways – AmaMagdalena
5.01 Reviews
Departs Nov 28, 2026 from Barranquilla, Colombia
Up to 3 deals including an Avoya Exclusive
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7-night south america cruise
Balcony From
$4,449
AmaWaterways – AmaMelodia
Departs Dec 02, 2026 from Cartagena, Colombia
Up to 2 deals
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7-night south america cruise
Balcony From
$5,348
AmaWaterways – AmaMagdalena
5.01 Reviews
Departs Dec 12, 2026 from Barranquilla, Colombia
Up to 2 deals
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7-night south america cruise
Balcony From
$5,548
AmaWaterways – AmaMelodia
Departs Dec 23, 2026 from Barranquilla, Colombia
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70-night south america cruise
Inside From
$13,599
Holland America – Zaandam
4.5133 Reviews
Departs Jan 03, 2027 from Fort Lauderdale, Florida
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20-night south america cruise
Suite From
$14,550
Silversea – Silver Nova
5.05 Reviews
Departs Jan 18, 2027 from Bridgetown, Barbados
Up to 3 deals including an Avoya Exclusive
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29-night south america cruise
Inside From
$5,999
Holland America – Zaandam
4.5133 Reviews
Departs Feb 13, 2027 from Buenos Aires, Argentina
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11-night south america cruise
Suite From
$12,650
Silversea – Silver Cloud
4.316 Reviews
Departs Feb 27, 2027 from Puerto Williams, Chile
Up to 3 deals including an Avoya Exclusive
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7-night south america cruise
Balcony From
$5,098
AmaWaterways – AmaMelodia
Departs Mar 31, 2027 from Barranquilla, Colombia
Up to 2 deals
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7-night south america cruise
Balcony From
$4,448
AmaWaterways – AmaMelodia
Departs Apr 14, 2027 from Barranquilla, Colombia
Up to 2 deals
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7-night south america cruise
Balcony From
$4,898
AmaWaterways – AmaMagdalena
5.01 Reviews
Departs May 01, 2027 from Barranquilla, Colombia
Up to 2 deals
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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