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Best South America Cruises

Showing 201-225 of 826 results
15-night south america cruise
Inside From
$2,925
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Nov 21, 2028 from Buenos Aires, Argentina
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21-night south america cruise + tour
Inside From
$7,075
Princess Cruises – Majestic Princess
4.468 Reviews
Departs Nov 21, 2028 from Buenos Aires, Argentina
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10-night south america cruise
Oceanview From
$4,099
50% Off List
Oceania Cruises – Aurelia
Departs Nov 22, 2028 from Rio de Janeiro, Brazil
Up to 2 deals including an Avoya Exclusive
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20-night south america cruise
Inside From
$6,799
50% Off List
Oceania Cruises – Aurelia
Departs Dec 02, 2028 from Buenos Aires, Argentina
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Balcony From
$4,579
AmaWaterways – AmaMelodia
Departs Dec 13, 2028 from Cartagena, Colombia
Up to 1 deal including an Avoya Exclusive
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7-night south america cruise
Balcony From
$4,579
AmaWaterways – AmaMagdalena
5.01 Reviews
Departs Dec 16, 2028 from Cartagena, Colombia
Up to 1 deal including an Avoya Exclusive
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15-night south america cruise
Inside From
$4,799
50% Off List
Oceania Cruises – Aurelia
Departs Dec 22, 2028 from Lima (Callao), Peru
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Balcony From
$4,679
AmaWaterways – AmaMagdalena
5.01 Reviews
Departs Dec 23, 2028 from Barranquilla, Colombia
Up to 1 deal including an Avoya Exclusive
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20-night south america cruise
Suite From
$16,830
Silversea – Silver Nova
5.05 Reviews
Departs Jan 22, 2029 from Bridgetown, Barbados
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10-night south america cruise
Suite From
$8,585
Silversea – Silver Nova
5.05 Reviews
Departs Feb 11, 2029 from Rio de Janeiro, Brazil
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18-night south america cruise
Suite From
$15,130
Silversea – Silver Nova
5.05 Reviews
Departs Feb 21, 2029 from Buenos Aires, Argentina
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18-night south america cruise
Suite From
$12,975
Silversea – Silver Nova
5.05 Reviews
Departs Mar 11, 2029 from Santiago (Valparaiso), Chile
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21-night south america cruise + tour
Suite From
$20,998
Seabourn – Seabourn Venture
5.02 Reviews
Departs Nov 18, 2026 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Secret Rate
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3-night south america cruise
Inside From
$408
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Nov 23, 2026 from Santos, Brazil
Up to 3 deals
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4-night south america cruise
Balcony From
$776
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Nov 26, 2026 from Santos, Brazil
Up to 3 deals
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3-night south america cruise
Oceanview From
$469
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Nov 30, 2026 from Santos, Brazil
Up to 3 deals
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3-night south america cruise
Inside From
$408
49% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 03, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Inside From
$1,079
48% Off List
MSC Cruises – MSC Virtuosa
5.01 Reviews
Departs Dec 05, 2026 from Santos, Brazil
Up to 3 deals
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7-night south america cruise
Oceanview From
$3,520
Windstar Cruises – Wind Star
4.689 Reviews
Departs Dec 05, 2026 from Colon, Panama
Up to 1 deal including an Avoya Exclusive
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4-night south america cruise
Inside From
$535
50% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 06, 2026 from Santos, Brazil
Up to 3 deals
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3-night south america cruise
Inside From
$468
40% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 10, 2026 from Santos, Brazil
Up to 3 deals
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8-night south america cruise
Oceanview From
$3,246
Windstar Cruises – Star Legend
4.586 Reviews
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
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7-night south america cruise
Oceanview From
$3,520
Windstar Cruises – Wind Star
4.689 Reviews
Departs Dec 12, 2026 from Puerto Caldera (Puntarenas), Costa Rica
Up to 2 deals including an Avoya Exclusive
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16-night south america cruise
Oceanview From
$5,628
Windstar Cruises – Star Legend
4.586 Reviews
Departs Dec 12, 2026 from Oranjestad, Aruba
Up to 2 deals including an Avoya Exclusive
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4-night south america cruise
Inside From
$525
50% Off List
MSC Cruises – MSC Musica
3.54 Reviews
Departs Dec 13, 2026 from Santos, Brazil
Up to 3 deals
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South America Cruises Overview

Experience the lifestyles and cultures in South America by enjoying rain forests, palm trees, sprawling cities, and several natural wonders. South America is filled with lively metropolitan cities, mysterious caves and canyons, and more, and a cruise to South America is one of the best ways to explore this spectacular continent.

Cruises through South America take guests to a variety of ports in countries including Argentina, Brazil, and Chile. Several sailings will also take travelers around the southern tip of South America and along the coast of Antarctica, where passengers can view the icy glaciers of the remote continent and striking wildlife including penguins and whales.

Passengers can visit the mansions of Palermo in the elegant city of Buenos Aires, Argentina; the skyscrapers in the bustling city of Santiago, Chile; the colonial architecture in the stunning city of Lima, Peru; and more. Travelers can also enjoy a night out in the vibrant city of Rio de Janeiro in Brazil while experiencing the invigorating lifestyle of locals, and the string of volcanoes on the Galapagos Islands, which provides travelers with views of tortoises, flamingos, and iguanas.

Local cuisine consists of hefty meals including meat and potatoes, flat bread, chorizo, tasty fruit juices, and more. Cruisers can also learn traditional dances such as the tango, and gain insight into the historical stories and customs of the local gauchos. With so many cultures and sights, cruising around South America allows travelers to sample and experience a diverse mixture of everything the colorful continent has to offer.

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