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MSC Cruises to Caribbean

Onboard an MSC Cruises Caribbean vacation, guests will enjoy all that the Caribbean has to offer with a cruise line that is focused on providing family fun with a distinctly Italian elegance. MSC Cruise Line features the MSC Poesia in the Caribbean, with cruise vacation itineraries that include over 23 destinations and countless unforgettable shore excursions. On all MSC Cruises to the Caribbean, kids sail free, ensuring that each of MSC Cruises’ Caribbean cruises are a great value and a perfect choice for family getaways.

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Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

Meet Natalie Thompson, one of Avoya's trusted travel advisors.

Our team has helped more than 2.5 million travelers save time, save money, and book their perfect vacation.

Choose your adventure and let us handle the rest.

Your dedicated Personal Travel Advisor is here to help you plan the vacation of your dreams. From finding the best price to answering every question, we are with you every step of the way at no extra cost.

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$869

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 21, 2028 View Other Dates →

Ports:

Fort de France → Saint Johns → La Romana → Catalina Island Dominican Republic → Bridgetown → Fort de France

Departs Apr 21, 2028 from Fort de France, Martinique

Up to 2 deals

Inside From

$869

49% Off List

List Price

$1,709

View Expanded Details

MSC Cruises MSC World Atlantic itinerary map

14-night caribbean cruise

Inside From

$1,770

48% Off List

MSC Cruises – MSC World Atlantic

Date:

Apr 22, 2028 View Other Dates →

Ports:

Departs Apr 22, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$1,770

48% Off List

List Price

$3,396

View Expanded Details

MSC Cruises MSC Seaside itinerary map

4-night caribbean cruise

Inside From

$466

45% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Apr 24, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs Apr 24, 2028 from Miami, Florida

Up to 3 deals

Inside From

$466

45% Off List

List Price

$847

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$759

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 24, 2028 View Other Dates →

Ports:

Departs Apr 24, 2028 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$759

49% Off List

List Price

$1,489

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,458

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 24, 2028 View Other Dates →

Ports:

Departs Apr 24, 2028 from La Romana, Dominican Republic

Up to 1 deal

Inside From

$1,458

49% Off List

List Price

$2,846

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

3-night caribbean cruise

Inside From

$443

46% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Apr 27, 2028 View Other Dates →

Ports:

Port Canaveral → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Port Canaveral

Departs Apr 27, 2028 from Port Canaveral, Florida

Up to 3 deals

Inside From

$443

46% Off List

List Price

$816

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,659

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 27, 2028 View Other Dates →

Ports:

Departs Apr 27, 2028 from Bridgetown, Barbados

Up to 1 deal

Inside From

$1,659

49% Off List

List Price

$3,248

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Inside From

$359

44% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

Apr 28, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs Apr 28, 2028 from Miami, Florida

Up to 2 deals

Inside From

$359

44% Off List

List Price

$643

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$779

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

Apr 28, 2028 View Other Dates →

Ports:

Departs Apr 28, 2028 from Fort de France, Martinique

Up to 2 deals

Inside From

$779

49% Off List

List Price

$1,529

View Expanded Details

MSC Cruises MSC World Atlantic itinerary map

14-night caribbean cruise

Inside From

$1,702

48% Off List

MSC Cruises – MSC World Atlantic

Date:

Apr 29, 2028 View Other Dates →

Ports:

Departs Apr 29, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$1,702

48% Off List

List Price

$3,260

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

4-night caribbean cruise

Inside From

$450

46% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

Apr 30, 2028 View Other Dates →

Ports:

Port Canaveral → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Port Canaveral

Departs Apr 30, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$450

46% Off List

List Price

$840

View Expanded Details

MSC Cruises MSC Seaside itinerary map

4-night caribbean cruise

Inside From

$366

43% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

May 01, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs May 01, 2028 from Miami, Florida

Up to 2 deals

Inside From

$366

43% Off List

List Price

$647

View Expanded Details

MSC Cruises MSC Seaside itinerary map

7-night caribbean cruise

Inside From

$681

47% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

May 01, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami → Nassau → Miami

Departs May 01, 2028 from Miami, Florida

Up to 2 deals

Inside From

$681

47% Off List

List Price

$1,276

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$749

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 01, 2028 View Other Dates →

Ports:

Departs May 01, 2028 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$749

49% Off List

List Price

$1,469

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,510

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 01, 2028 View Other Dates →

Ports:

Departs May 01, 2028 from La Romana, Dominican Republic

Up to 1 deal

Inside From

$1,510

49% Off List

List Price

$2,950

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

3-night caribbean cruise

Inside From

$473

46% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

May 04, 2028 View Other Dates →

Ports:

Port Canaveral → Nassau → Ocean Cay MSC Marine Reserve Bahamas → Port Canaveral

Departs May 04, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$473

46% Off List

List Price

$876

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Inside From

$349

44% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

May 05, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs May 05, 2028 from Miami, Florida

Up to 2 deals

Inside From

$349

44% Off List

List Price

$623

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$788

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 05, 2028 View Other Dates →

Ports:

Fort de France → Saint Johns → La Romana → Catalina Island Dominican Republic → Bridgetown → Fort de France

Departs May 05, 2028 from Fort de France, Martinique

Up to 2 deals

Inside From

$788

49% Off List

List Price

$1,547

View Expanded Details

MSC Cruises MSC Seascape itinerary map

7-night caribbean cruise

Inside From

$715

49% Off List

MSC Cruises – MSC Seascape

4.120 Reviews

Date:

May 07, 2028 View Other Dates →

Ports:

Galveston → Costa Maya → Roatan → Cozumel → Galveston

Departs May 07, 2028 from Galveston, Texas

Up to 2 deals

Inside From

$715

49% Off List

List Price

$1,415

View Expanded Details

MSC Cruises MSC Seaside itinerary map

4-night caribbean cruise

Inside From

$366

43% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

May 08, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs May 08, 2028 from Miami, Florida

Up to 2 deals

Inside From

$366

43% Off List

List Price

$647

View Expanded Details

MSC Cruises MSC Opera itinerary map

7-night caribbean cruise

Inside From

$749

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 08, 2028 View Other Dates →

Ports:

Departs May 08, 2028 from La Romana, Dominican Republic

Up to 2 deals

Inside From

$749

49% Off List

List Price

$1,469

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,550

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 08, 2028 View Other Dates →

Ports:

Departs May 08, 2028 from La Romana, Dominican Republic

Up to 1 deal

Inside From

$1,550

49% Off List

List Price

$3,030

View Expanded Details

MSC Cruises MSC Grandiosa itinerary map

3-night caribbean cruise

Inside From

$403

45% Off List

MSC Cruises – MSC Grandiosa

5.02 Reviews

Date:

May 11, 2028 View Other Dates →

Ports:

Port Canaveral → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Port Canaveral

Departs May 11, 2028 from Port Canaveral, Florida

Up to 2 deals

Inside From

$403

45% Off List

List Price

$736

View Expanded Details

MSC Cruises MSC Opera itinerary map

14-night caribbean cruise

Inside From

$1,629

49% Off List

MSC Cruises – MSC Opera

4.05 Reviews

Date:

May 11, 2028 View Other Dates →

Ports:

Departs May 11, 2028 from Bridgetown, Barbados

Up to 1 deal

Inside From

$1,629

49% Off List

List Price

$3,188

View Expanded Details

MSC Cruises MSC Seaside itinerary map

3-night caribbean cruise

Inside From

$349

44% Off List

MSC Cruises – MSC Seaside

3.575 Reviews

Date:

May 12, 2028 View Other Dates →

Ports:

Miami → Ocean Cay MSC Marine Reserve Bahamas → Nassau → Miami

Departs May 12, 2028 from Miami, Florida

Up to 2 deals

Inside From

$349

44% Off List

List Price

$623

View Expanded Details

Showing 751-775 of 1,181 results

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